Evidence map›Paper›PMID 29750131›Full record

ArticleMRS communications2017

Tissue engineering toward organ-specific regeneration and disease modeling.

Christian Mandrycky, Kiet Phong, Ying Zheng

Abstract read
In one paragraph

Article in MRS communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. 3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Tissue chips as headway model and incitement technology.Synthetic and systems biotechnology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Current Advances in 3D Tissue and Organ Reconstruction.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christian MandryckyDepartments of Bioengineering, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Kiet PhongDepartments of Bioengineering, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Ying ZhengDepartments of Bioengineering, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.

Funding

A Microfluidic Bone Marrow Niche for the Study of HematopoiesisDP2DK102258 · NIDDK · UNIVERSITY OF WASHINGTON · PI ZHENG, YING · 2013 to 2013
$2.6M
3D human-based microvessel bed for the study of Plasmodium falciparum interacting with vessel wallR01HL130488 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI SMITH, JOSEPH D, ZHENG, YING · 2015 to 2018
$2.3M
Rebuilding the glomerular filtration barrier by regenerating adult podocytesUH3DK107343 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, ZHENG, YING · 2017 to 2019
$1.3M
Rebuilding the glomerular filtration barrier by regenerating adult podocytesUH2DK107343 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, ZHENG, YING · 2015 to 2016
$855k
NHLBI NIH HHS R01 HL130488NIDDK NIH HHS DP2 DK102258NIDDK NIH HHS UH2 DK107343NIDDK NIH HHS UH3 DK107343
6 · The paper itself

Abstract

Tissue engineering has been recognized as a translational approach to replace damaged tissue or whole organs. Engineering tissue, however, faces an outstanding knowledge gap in the challenge to fully recapitulate complex organ-specific features. Major components, such as cells, matrix, and architecture, must each be carefully controlled to engineer tissue-specific structure and function that mimics what is found in vivo. Here we review different methods to engineer tissue, and discuss critical challenges in recapitulating the unique features and functional units in four major organs-the kidney, liver, heart, and lung, which are also the top four candidates for organ transplantation in the USA. We highlight advances in tissue engineering approaches to enable the regeneration of complex tissue and organ substitutes, and provide tissue-specific models for drug testing and disease modeling. We discuss the current challenges and future perspectives toward engineering human tissue models.

Identifiers

PMID29750131
PMCPMC5939579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.