Evidence map›Paper›PMID 29750035›Full record

ArticleNeuropsychiatric disease and treatment2018

Antidepressant medication use and nasopharyngeal cancer risk: a nationwide population-based study.

Chiao-Fan Lin, Hsiang-Lin Chan, Yi-Hsuan Hsieh, Hsin-Yi Liang, Wei-Che Chiu, Yena Lee, Roger S McIntyre, Vincent Chin-Hung Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chiao-Fan Lin *Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hsiang-Lin ChanDepartment of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yi-Hsuan HsiehDepartment of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hsin-Yi LiangDepartment of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Wei-Che Chiu *Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan.
Yena LeeMood Disorders Psychopharmacology Unit, Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada.
Roger S McIntyreMood Disorders Psychopharmacology Unit, Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada.
Vincent Chin-Hung ChenDepartment of Psychiatry, Chang Gung University, Taoyuan, Taiwan.
Chang Gung University · TWBrain and Cognition Discovery Foundation · CAFu Jen Catholic University · TWUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between antidepressant exposure and nasopharyngeal cancer (NPC) has not been previously explored. The purpose of this study was to investigate the association between antidepressant prescription, including novel antidepressants, and the risk of NPC in a population-based study. MATERIALS AND

methodsData for the analysis were derived from National Health Insurance Research Database. We identified 16,957 cases with a diagnosis of NPC and 83,231 matched controls by using a nested case-control design. A conditional logistic regression model was used, with adjustments for potentially confounding variables (eg, comorbid physical diseases, comorbid psychiatric diseases, and other medications).

resultsWe report no association between NPC incidence and antidepressant prescription. For all classes of antidepressants, antidepressant exposure, regardless of cumulative dose, had no significant effect on NPC incidence (adjusted odds ratio of cumulative selective serotonin reuptake inhibitor exposure ≥336 defined daily dose was 1.18 [95% CI: 0.90-1.53]; tricyclic antidepressant exposure ≥336 defined daily dose was 1.18 [95% CI: 0.80-1.74]).

conclusionThere was no association between antidepressant prescription and incident NPC.

Indexed as

antidepressantsnasopharyngeal cancerTaiwan national insurance

Identifiers

PMID29750035
PMCPMC5933360
OpenAlexW2801702401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.