Evidence map›Paper›PMID 29749710›Full record

SynthesisEarly intervention in psychiatry2019

Attenuated psychotic symptom interventions in youth at risk of psychosis: A systematic review and meta-analysis.

Daniel J Devoe, Megan S Farris, Parker Townes, Jean Addington

Open access · bronzeAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Early intervention in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 12 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 12 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  11. Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Daniel J DevoeDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
Megan S FarrisDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
Parker TownesDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.ORCID 0000-0002-8298-0756
Allen Institute for Brain Science · US

Funding

3 Cognitive Behavioral Social Skills Training for Youth at Risk of PsychosisR01MH105178 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2014 to 2018
$1.4M
NIMH NIH HHS R01 MH105178NIMH NIH HHS RO1MH105178
6 · The paper itself

Abstract

aimAttenuated psychotic symptoms (APSs) have been the primary emphasis in youth at clinical high risk (CHR) for psychosis for assessing symptomology and determining subsequent transition to a psychotic disorder. Previous reviews primarily focused on the efficacy of cognitive behavioural therapy (CBT) on APS; however, a comprehensive assessment of other interventions to date is lacking. Therefore, we conducted a systematic review and meta-analysis of all intervention studies examining APS in CHR youth.

methodThe authors searched Embase, CINAHL, PsycINFO, Medline and EBM from inception to May 2017. Studies were selected if they included any intervention that reported follow-up APS in youth at CHR. Interventions were evaluated and stratified by time using both pairwise and network meta-analyses (NMAs). Due to the differences in APS scales, effect sizes were calculated as Hedges g and reported as the standardized mean difference (SMD).

resultsForty-one studies met our inclusion criteria. In pairwise meta-analyses, CBT was associated with a trend towards reduction in APS compared to controls at 12-months. In the NMA, integrated psychological therapy, CBT, supportive therapy, family therapy, needs-based interventions, omega-3, risperidone plus CBT and olanzapine were not significantly more effective at reducing APS at 6 and 12 months relative to any other intervention.

conclusionsCBT demonstrated a slight trend at reducing APS at long-term follow-up compared to controls. No interventions were significantly more effective at reducing APS compared to all other interventions in the NMA. [Correction added on 4 June 2018, after first online publication: Some parts of the Abstract section particularly 'Results' and 'Conclusions' have been corrected.].

Indexed as

PsychotherapyAntipsychotic AgentsFatty Acids, Omega-3HumansPsychotic DisordersAntipsychotic AgentsFatty Acids, Omega-3clinical high riskmeta-analysisschizophreniasystematic review

Identifiers

PMID29749710
PMCPMC6230498
OpenAlexW2801531060

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.