ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2018
The Role of Neuroimaging in the Determination of Brain Death.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Initial CT Imaging Predicts Mortality in Severe Traumatic Brain Injuries in Pediatric Population-A Systematic Review and Meta-Analysis.Tomography (Ann Arbor, Mich.) · 2023Pooled it
- Prevalence, semiology and neuroimaging of movements in comatose adults at risk of death by neurologic criteria: a prospective cohort study.Critical care (London, England) · 2026Trial
- Review
- Computed tomography perfusion assessment of poor neurological outcome in comatose cardiac arrest patients (CANCCAP): a prospective study.Critical care (London, England) · 2025Article
- Computed Tomography Angiography as Ancillary Testing for Death Determination by Neurologic Criteria: A Technical Review.Tomography (Ann Arbor, Mich.) · 2024Review
- Role of Clinical and Multimodality Neuroimaging in the Evaluation of Brain Death/Death by Neurologic Criteria and Recent Highlights from 2023 Updated Guidelines.Diagnostics (Basel, Switzerland) · 2024Review
- Ancillary tests for brain death.Frontiers in neurology · 2024Review
- Measuring brain perfusion by CT or MR as ancillary tests for diagnosis of brain death: a systematic review and meta-analysis.BJR open · 2024Article
- Article
- Article
- Computed Tomography Angiography (CTA) in Selected Scenarios with Risk of Possible False-Positive or False-Negative Conclusions in Diagnosing Brain Death.Life (Basel, Switzerland) · 2022Review
- Possible additional MRI markers for critical brain swelling with increased intracranial pressure in children?The neuroradiology journal · 2021Article
- Variation in CT perfusion protocol has implications on defining irreversibly damaged ischemic brain parenchyma.European radiology · 2021Article
- Flow is not perfusion, and perfusion is not function: ancillary testing for the diagnosis of brain death.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- Article
- Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury.Frontiers in neurology · 2021Review
- Diagnostic Value of Perfusion MR Imaging as a Potential Ancillary Test for Brain Death.Journal of the Belgian Society of Radiology · 2020Article
- Implementing of Active Brain-Dead Donor Identification Strategy in a Single Donor Center: One Year Experience.Medicina (Kaunas, Lithuania) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeBrain death determination (BDD) is primarily a clinical diagnosis, where death is defined as the permanent loss of brainstem function. In scenarios where clinical examinations are inaccurate, ancillary imaging tests are required. The choice of ancillary imaging test is variable, but the common denominator for all of them is to establish a lack of cerebral blood flow. The purpose of this study was to compare the diagnostic accuracy and interrater reliability of different ancillary imaging tests used for BDD.
methodsArchival data were retrospectively analyzed for all patients who underwent any ancillary imaging test for BDD at our institution. The results of ancillary imaging tests were compared with, the reference standard, the clinical checklist for declaration of brain death. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of different ancillary imaging tests for BDD were performed. Interobserver agreement between two observers was measured using kappa statistics for each of the imaging modalities.
resultsA total of 74 patients underwent 41 computer tomography perfusion (CTP), 54 CT angiogram, 15 radionuclide scans, 1 cerebral angiogram, 3 magnetic resonance imaging, and 71 nonenhanced CT (NECT) head for BDD. All ancillary tests (except NECT head) showed 100% specificity and PPV. CTP had the highest sensitivity and NPV. All ancillary imaging tests demonstrated very high interrater reliability.
conclusionsThe uses of ancillary imaging tests for BDD are increasing. Within this study's limitations, CTP followed by radionuclide scan were found to be the most accurate and reliable ancillary imaging test for BDD.
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Registered trials
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