Evidence map›Paper›PMID 29749651›Full record

Trial reportJournal of veterinary internal medicine2018

Effects of immunosuppressive agents on the hemostatic system in normal dogs.

John M Thomason, Todd M Archer, Robert W Wills, Andrew J Mackin

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of veterinary internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Urinary 11-dehydrothromboxane BJournal of veterinary internal medicine · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

John M ThomasonDepartment of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.ORCID http://orcid.org/0000-0001-5678-8923
Todd M ArcherDepartment of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.
Robert W WillsDepartment of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.
Andrew J MackinDepartment of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi.
Mississippi State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn dogs, the effects of immunosuppressive medications on hemostasis are not well known. HYPOTHESIS/

objectivesThe objective was to determine the effects of immunosuppressive medications on primary and secondary hemostasis. Our hypothesis was that cyclosporine and prednisone would increase markers of hypercoagulability and thromboxane synthesis, while azathioprine, mycophenolate mofetil, and leflunomide would have minimal effects on hemostasis. ANIMALS: Eight healthy dogs.

methodsA randomized, cross-over study used aggregometry, the PFA-100 platelet function analyzer, viscoelastometry, platelet count, and prothrombin and activated partial thromboplastin times to evaluate hemostasis during the administration of prednisone, azathioprine, cyclosporine, mycophenolate mofetil, and leflunomide for 1 week each at standard oral doses. Urine 11-dehydro-thromboxane-B

resultsThe aggregometry amplitude decreased from 51 ± 21 to 27 ± 14 (P = .002) during leflunomide treatment (ADP activation), but there were no differences in amplitude (P = .240) for any medications when platelets were activated with collagen. For all medications, there were no significant differences in viscoelastometry indices (ACT, P = .666; ClotRate, P = .340; and platelet function, P = .411) and platelet count (P = .552). Compared with pretreatment values, urinary 11-dTXB CONCLUSIONS AND CLINICAL IMPORTANCE: Most immunosuppressive drugs do not enhance platelet function or coagulation in healthy dogs, suggesting that these medications might not predispose hypercoagulable dogs to thromboembolism. The results of our study need to be correlated with the clinical outcomes of hypercoagulable dogs.

Indexed as

6-Ketoprostaglandin F1 alphaAnimalsAzathioprineBlood CoagulationBlood PlateletsCreatinineCross-Over StudiesCyclosporineDogsFemaleHemostasisImmunosuppressive AgentsIsoxazolesLeflunomideMaleMycophenolic Acid11-dehydro-thromboxane B26-Ketoprostaglandin F1 alphaAzathioprineCreatinineCyclosporineImmunosuppressive AgentsIsoxazolesLeflunomideMycophenolic AcidPrednisoneThromboxane B2cyclosporineplateletsprostacyclinthromboxane

Identifiers

PMID29749651
PMCPMC6060322
OpenAlexW2801294226

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.