Evidence map›Paper›PMID 29749580›Full record

ArticleJournal of industrial microbiology & biotechnology2018

An economically and environmentally acceptable synthesis of chiral drug intermediate L-pipecolic acid from biomass-derived lysine via artificially engineered microbes.

Jie Cheng, Yuding Huang, Le Mi, Wujiu Chen, Dan Wang, Qinhong Wang

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. An Artificial Pathway forFrontiers in microbiology · 2022
    Article
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jie ChengKey Laboratory of Chemical Process for Clean Energy and Resource Utilization, Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, People's Republic of China.
Yuding HuangKey Laboratory of Chemical Process for Clean Energy and Resource Utilization, Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, People's Republic of China.
Le MiKey Laboratory of Chemical Process for Clean Energy and Resource Utilization, Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, People's Republic of China.
Wujiu ChenKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.
Dan WangKey Laboratory of Chemical Process for Clean Energy and Resource Utilization, Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, People's Republic of China. dwang@cqu.edu.cn.
Qinhong WangKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. wang_qh@tib.cas.cn.
Chinese Academy of Sciences · CNChongqing University · CNTianjin Institute of Industrial Biotechnology · CN

Funding

Open Funding Project of the State Key Laboratory of Bioreactor Engineering, Shanghai, China 1the Fundamental Research Funds for the Central Universities 106112017CDJXFLX0014the Henan Provincial Science and technology Open cooperation projects 162106000014the Industrial Biotechnology Program of Tianjin Municipal Science and Technology Commission 14ZCZDSY00066
6 · The paper itself

Abstract

Deficiency in petroleum resources and increasing environmental concerns have pushed a bio-based economy to be built, employing a highly reproducible, metal contaminant free, sustainable and green biomanufacturing method. Here, a chiral drug intermediate L-pipecolic acid has been synthesized from biomass-derived lysine. This artificial bioconversion system involves the coexpression of four functional genes, which encode L-lysine α-oxidase from Scomber japonicus, glucose dehydrogenase from Bacillus subtilis, Δ

Indexed as

BiomassAmino Acid OxidoreductasesBacillus subtilisChemistry, PharmaceuticalEscherichia coliFermentationGlucose 1-DehydrogenaseGreen Chemistry TechnologyIndustrial MicrobiologyLysineMetabolic EngineeringPipecolic AcidsPlasmidsPseudomonas putidaStereoisomerismAmino Acid OxidoreductasesGlucose 1-DehydrogenaseL-lysine oxidaseLysinepipecolic acidPipecolic AcidsArtificial pathwayBiomanufacturingL-LysineL-Pipecolic acidLysine permease

Identifiers

PMID29749580
OpenAlexW2800302228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.