Evidence map›Paper›PMID 29749576›Full record

ArticleEmergency radiology2018

Clinical outcomes after magnetic resonance angiography (MRA) versus computed tomographic angiography (CTA) for pulmonary embolism evaluation.

Michael D Repplinger, Scott K Nagle, John B Harringa, Aimee T Broman, Christopher R Lindholm, Christopher J François, Thomas M Grist, Scott B Reeder, Mark L Schiebler

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Emergency radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. State-of-the-Art Imaging for the Evaluation of Pulmonary Embolism.Current treatment options in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael D RepplingerBerbeeWalsh Department of Emergency Medicine, University of Wisconsin, 800 University Bay Drive, Suite 310, Mail Code 9123, Madison, WI, 53705, USA. mdrepplinger@wisc.edu.
Scott K NagleDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
John B HarringaBerbeeWalsh Department of Emergency Medicine, University of Wisconsin, 800 University Bay Drive, Suite 310, Mail Code 9123, Madison, WI, 53705, USA.
Aimee T BromanDepartment of Biostatistics, University of Wisconsin, Madison, WI, USA.
Christopher R LindholmDepartment of Medicine, Dartmouth University, Geisel School of Medicine, Hanover, NH, USA.
Christopher J FrançoisBerbeeWalsh Department of Emergency Medicine, University of Wisconsin, 800 University Bay Drive, Suite 310, Mail Code 9123, Madison, WI, 53705, USA.
Thomas M GristDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Scott B ReederBerbeeWalsh Department of Emergency Medicine, University of Wisconsin, 800 University Bay Drive, Suite 310, Mail Code 9123, Madison, WI, 53705, USA.
Mark L SchieblerDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
University of Wisconsin–Madison · USDartmouth College · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
Identifying Barriers and Facilitators to the Implementation of Radiation-Free Imaging Protocols in the Emergency DepartmentK08DK111234 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REPPLINGER, MICHAEL DEAN · 2016 to 2018
$488k
NCATS NIH HHS KL2 TR000428NCATS NIH HHS KL2TR000428NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1TR000427NCATS NIH HHS UL1 TR002373NIDDK NIH HHS K08 DK111234NIDDK NIH HHS K08DK111234NIDDK NIH HHS K24 DK102595NIDDK NIH HHS K24DK102595NIDDK NIH HHS L30 DK106864
6 · The paper itself

Abstract

purposeTo compare patient outcomes following magnetic resonance angiography (MRA) versus computed tomographic angiography (CTA) ordered for suspected pulmonary embolism (PE).

methodsIn this IRB-approved, single-center, retrospective, case-control study, we reviewed the medical records of all patients evaluated for PE with MRA during a 5-year period along with age- and sex-matched controls evaluated with CTA. Only the first instance of PE evaluation during the study period was included. After application of our exclusion criteria to both study arms, the analysis included 1173 subjects. The primary endpoint was major adverse PE-related event (MAPE), which we defined as major bleeding, venous thromboembolism, or death during the 6 months following the index imaging test (MRA or CTA), obtained through medical record review. Logistic regression, chi-square test for independence, and Fisher's exact test were used with a p < 0.05 threshold.

resultsThe overall 6-month MAPE rate following MRA (5.4%) was lower than following CTA (13.6%, p < 0.01). Amongst outpatients, the MAPE rate was lower for MRA (3.7%) than for CTA (8.0%, p = 0.01). Accounting for age, sex, referral source, BMI, and Wells' score, patients were less likely to suffer MAPE than those who underwent CTA, with an odds ratio of 0.44 [0.24, 0.80]. Technical success rate did not differ significantly between MRA (92.6%) and CTA (90.5%) groups (p = 0.41).

conclusionWithin the inherent limitations of a retrospective case-controlled analysis, we observed that the rate of MAPE was lower (more favorable) for patients following pulmonary MRA for the primary evaluation of suspected PE than following CTA.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersCase-Control StudiesComputed Tomography AngiographyDiagnosis, DifferentialFemaleHumansMagnetic Resonance AngiographyMaleMiddle AgedPulmonary EmbolismRetrospective StudiesRisk FactorsBiomarkersClinical effectivenessComputed tomographic angiographyMagnetic resonance angiographyPatient-oriented outcomesPulmonary embolism

Identifiers

PMID29749576
PMCPMC6119517
OpenAlexW2802897036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.