ArticleScientific reports2018
3D confocal laser-scanning microscopy for large-area imaging of the corneal subbasal nerve plexus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Large-area 3D reconstruction of corneal tissues from oscillating focus confocal microscopy.Scientific reports · 2026Article
- CORONIS symposium 2023: Scientific and clinical frontiers in ocular surface innervation.Acta ophthalmologica · 2025Article
- Deep Corneal Nerve Plexus Selective Damage in Persistent Neurotrophic Corneal Epithelial Defects Detected by In Vivo Multiphoton Confocal Microscopy.Investigative ophthalmology & visual science · 2025Article
- Non-contact confocal calcium imaging ofBiomedical optics express · 2025Article
- Applications of Imaging Technologies in Fuchs Endothelial Corneal Dystrophy: A Narrative Literature Review.Bioengineering (Basel, Switzerland) · 2024Review
- Automated Image Registration Method for In Vivo Confocal Microscopy of the Corneal Sub-basal Nerve Plexus.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Taxane-Induced Neuropathy and Its Ocular Effects-A Longitudinal Follow-up Study in Breast Cancer Patients.Cancers · 2023Article
- Mosaic vs. Single Image Analysis with Confocal Microscopy of the Corneal Nerve Plexus for Diagnosis of Early Diabetic Peripheral Neuropathy.Ophthalmology and therapy · 2022Article
- Assessment of dynamic corneal nerve changes using static landmarks byQuantitative imaging in medicine and surgery · 2022Article
- In Vivo Monitoring of Corneal Dendritic Cells in the Subbasal Nerve Plexus during Trastuzumab and Paclitaxel Breast Cancer Therapy-A One-Year Follow-Up.Diagnostics (Basel, Switzerland) · 2022Article
- Real-time large-area imaging of the corneal subbasal nerve plexus.Scientific reports · 2022Article
- In Vivo Confocal Microscopy Evaluation in Patients with Keratoconus.Journal of clinical medicine · 2022Review
- Semiautomated and Automated Quantitative Analysis of Corneal Sub-Basal Nerves in Patients With DED With Ocular Pain Using IVCM.Frontiers in medicine · 2022Article
- Burst of Corneal Dendritic Cells during Trastuzumab and Paclitaxel Treatment.Diagnostics (Basel, Switzerland) · 2021Article
- Atypical Cellular Elements of Unknown Origin in the Subbasal Nerve Plexus of a Diabetic Cornea Diagnosed by Large-Area Confocal Laser Scanning Microscopy.Diagnostics (Basel, Switzerland) · 2021Article
- Current View of Diagnosing Small Fiber Neuropathy.Journal of neuromuscular diseases · 2021Review
- Small Fibre Neuropathy Is Associated With Impaired Vascular Endothelial Function in Patients With Type 2 Diabetes.Frontiers in endocrinology · 2021Observational
- Real-time non-contact cellular imaging and angiography of human cornea and limbus with common-path full-field/SD OCT.Nature communications · 2020Article
- C-Fiber Assays in the Cornea vs. Skin.Brain sciences · 2019Review
- CellularBiomedical optics express · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capability of corneal confocal microscopy (CCM) to acquire high-resolution in vivo images of the densely innervated human cornea has gained considerable interest in using this non-invasive technique as an objective diagnostic tool for staging peripheral neuropathies. Morphological alterations of the corneal subbasal nerve plexus (SNP) assessed by CCM have been shown to correlate well with the progression of neuropathic diseases and even predict future-incident neuropathy. Since the field of view of single CCM images is insufficient for reliable characterisation of nerve morphology, several image mosaicking techniques have been developed to facilitate the assessment of the SNP in large-area visualisations. Due to the limited depth of field of confocal microscopy, these approaches are highly sensitive to small deviations of the focus plane from the SNP layer. Our contribution proposes a new automated solution, combining guided eye movements for rapid expansion of the acquired SNP area and axial focus plane oscillations to guarantee complete imaging of the SNP. We present results of a feasibility study using the proposed setup to evaluate different oscillation settings. By comparing different image selection approaches, we show that automatic tissue classification algorithms are essential to create high-quality mosaic images from the acquired 3D datasets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.