ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2018
Prevalence of the integration status for human papillomavirus 16 in esophageal carcinoma samples.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- HPV prevalence in esophageal cancer: an updated systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Prevalence of HPV Infection Among Chinese Males With HPV-Related Diseases: A Systematic Review and Meta-Analysis.Journal of medical virology · 2025Pooled it
- Upper gastrointestinal tract microbiota with oral origin in relation to oesophageal squamous cell carcinoma.Annals of medicine · 2023Review
- HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China.Frontiers in public health · 2021Article
- Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers.Biomolecules · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo investigate the etiology of esophageal cancer (EC) related with human papillomavirus (HPV) infection. MATERIALS AND
methodsFresh surgically resected tissue samples and clinical information were obtained from 189 patients. Genomic DNA was extracted, and HPV was detected using polymerase chain reaction (PCR) with HPV L1 gene primers of MY09/11; HPV16 was detected using HPV16 E6 type-specific primer sets. Copies of HPV16 E2, E6, and the human housekeeping gene β-actin were tested using quantitative PCR to analyze the relationship between HPV16 integration and esophageal squamous cell carcinoma and the relationship between the HPV16 integration status and clinical information of patients.
resultsOf the 189 samples, 168 HPV-positive samples were detected, of which 76 were HPV16 positive. Among the HPV16 positive samples, 2 cases (E2/E6 ratio>1) were 2.6% (2/76) purely episomal, 65 (E2/E6 ratio between 0 and 1) were 85.6% (65/76) mixture of integrated and episomal, and 9 (E2/E6 ratio=0) were 11.8% (9/76) purely integrated. The results indicate that integration of HPV16 was more common in the host genome than in the episome genome. The prevalence rate of HPV16 integration is increasing with the pathological stage progression of esophageal carcinoma (EC).
conclusionA high prevalence of HPV16 suggested that HPV16 has an etiological effect on the progress of EC. Integration of HPV16 is more common than episome genome in the host cells, indicating that continuous HPV infection is the key to esophageal epithelial cell malignant conversion and canceration.
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