Evidence map›Paper›PMID 29749311›Full record

ReviewCurrent drug targets2018

Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature.

Dianaly T Au, Allison L Arai, William E Fondrie, Selen C Muratoglu, Dudley K Strickland

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current drug targets, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Lrp1 Regulation of Pulmonary Function. Follow-Up of Human GWAS in Mice.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dianaly T AuCenter for Vascular and Inflammatory Diseases, Biopark I, R213, 800 W. Baltimore Street, Baltimore, Maryland 21201, MD, United States.
Allison L AraiCenter for Vascular and Inflammatory Diseases, Biopark I, R213, 800 W. Baltimore Street, Baltimore, Maryland 21201, MD, United States.
William E FondrieCenter for Vascular and Inflammatory Diseases, Biopark I, R213, 800 W. Baltimore Street, Baltimore, Maryland 21201, MD, United States.
Selen C MuratogluCenter for Vascular and Inflammatory Diseases, Biopark I, R213, 800 W. Baltimore Street, Baltimore, Maryland 21201, MD, United States.
Dudley K StricklandCenter for Vascular and Inflammatory Diseases, Biopark I, R213, 800 W. Baltimore Street, Baltimore, Maryland 21201, MD, United States.
Center for Vascular Biology Research · US

Funding

Role of LDL receptor family members in protecting the vasculatureR35HL135743 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI STRICKLAND, DUDLEY K. · 2017 to 2023
$5.4M
Role of LRP1 in Angiotensin Signaling and Vascular RemodelingF31HL131293 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI AU, DIANALY THI · 2016 to 2017
$59k
Defining a mechanism of LRP1B tumor suppression in glioblastomaF31CA213815 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FONDRIE, WILLIAM ELLIS · 2017 to 2018
$36k
NCI NIH HHS F31 CA213815NHLBI NIH HHS F31 HL131293NHLBI NIH HHS R35 HL135743
6 · The paper itself

Abstract

Aortic aneurysms represent a significant clinical problem as they largely go undetected until a rupture occurs. Currently, an understanding of mechanisms leading to aneurysm formation is limited. Numerous studies clearly indicate that vascular smooth muscle cells play a major role in the development and response of the vasculature to hemodynamic changes and defects in these responses can lead to aneurysm formation. The LDL receptor-related protein 1 (LRP1) is major smooth muscle cell receptor that has the capacity to mediate the endocytosis of numerous ligands and to initiate and regulate signaling pathways. Genetic evidence in humans and mouse models reveal a critical role for LRP1 in maintaining the integrity of the vasculature. Understanding the mechanisms by which this is accomplished represents an important area of research, and likely involves LRP1's ability to regulate levels of proteases known to degrade the extracellular matrix as well as its ability to modulate signaling events.

Indexed as

AnimalsAortic AneurysmDisease Models, AnimalHumansLow Density Lipoprotein Receptor-Related Protein-1Myocytes, Smooth MusclePeptide HydrolasesPolymorphism, Single NucleotideSignal TransductionLow Density Lipoprotein Receptor-Related Protein-1LRP1 protein, humanPeptide Hydrolasesaneurysmsextracellular matrixLipoprotein receptorsLRP1proteasessmooth muscle cells.

Identifiers

PMID29749311
PMCPMC6812522
OpenAlexW2799983061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.