Evidence map›Paper›PMID 29749279›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019

Building a database for brain 18 kDa translocator protein imaged using [

Soumen Paul, Evan Gallagher, Jeih-San Liow, Sanche Mabins, Katharine Henry, Sami S Zoghbi, Roger N Gunn, William C Kreisl, Erica M Richards, Paolo Zanotti-Fregonara and 6 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  2. Review
  3. Article
  4. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Towards PET imaging of the dynamic phenotypes of microglia.Clinical and experimental immunology · 2021
    Review
  13. Cellular sources of TSPO expression in healthy and diseased brain.European journal of nuclear medicine and molecular imaging · 2021
    Review
  14. Article
  15. Article
  16. Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [European journal of nuclear medicine and molecular imaging · 2019
    Article
  17. Neuroinflammation in frontotemporal lobar degeneration revealed byAnnals of clinical and translational neurology · 2019
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Soumen Paul1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Evan Gallagher1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Jeih-San Liow1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Sanche Mabins1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Katharine Henry1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Sami S Zoghbi1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Roger N Gunn2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK; Imanova Centre for Imaging Sciences, London, UK.
William C Kreisl3 Taub Institute, Columbia University Medical Center, New York, NY, USA.
Erica M Richards1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Paolo Zanotti-Fregonara4 Houston Methodist Research Institute, Houston, TX, USA.
Cheryl L Morse1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Jinsoo Hong1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Aneta Kowalski1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Victor W Pike1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Robert B Innis1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Masahiro Fujita1 Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002852
6 · The paper itself

Abstract

Translocator protein 18 kDa (TSPO) has been widely imaged as a marker of neuroinflammation using several radioligands, including [

Indexed as

AcetamidesAdultAge FactorsBody Mass IndexBrainCarbon RadioisotopesFemaleHealthy VolunteersHumansMaleMiddle AgedPyridinesRadionuclide ImagingRadiopharmaceuticalsReceptors, GABASex FactorsAcetamidesCarbon RadioisotopesN-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamidePyridinesRadiopharmaceuticalsReceptors, GABATSPO protein, human[C]PBR28distribution volumehigh-affinity bindermixed-affinity binderTranslocator protein

Identifiers

PMID29749279
PMCPMC6547185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.