ArticleYonsei medical journal2018
Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population.
Article in Yonsei medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Whole-exome sequencing analysis identifies novel variants associated with Kawasaki disease susceptibility.Pediatric rheumatology online journal · 2023Article
- Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer.Bioscience reports · 2021Article
- Comprehensive analysis of Transcription Factors identified novel prognostic biomarker in human bladder cancer.Journal of Cancer · 2021Article
- Current State of Precision Medicine in Primary Systemic Vasculitides.Frontiers in immunology · 2019Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeKawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. MATERIALS AND
methodsAn SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods.
resultsPolymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0.040). The EBF2 gene polymorphisms were significantly associated with KD on logistic regression analysis.
conclusionEBF2 gene variants can contribute to KD in the Korean population.
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