Observational studyYonsei medical journal2018
Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea.
Observational study in Yonsei medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- [Modern capabilities of contrast-enhanced computed tomography in the diagnosis of adrenal adenomas].Problemy endokrinologii · 2026Article
- Consensus on the diagnosis of Cushing's disease: a collaborative statement from the Korean Endocrine Society and Japan Endocrine Society.Endocrine journal · 2026Article
- Clinical Outcomes and Predictive Factors in Adrenalectomy: A Retrospective Cohort Study.Iranian journal of pathology · 2026Article
- Identifying factors associated with subsequent diagnosis of adrenal adenoma: a population-based historical case-control study.European journal of endocrinology · 2025Article
- Sexual dimorphism in benign adrenocortical tumours.European journal of endocrinology · 2025Review
- High prevalence but low referral rate of adrenal incidentalomas in a Lebanese tertiary hospital.Frontiers in endocrinology · 2025Article
- Clinical and Metabolic Characteristics and Follow-Up Results of Adrenal Incidentalomas: A 10-Year Experience.Cureus · 2024Article
- The Spectrum of Adrenal Lesions in a Tertiary Referral Center.Biomedicines · 2024Article
- Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.Nature reviews. Endocrinology · 2024Review
- Clinical, radiological, and surgical outcomes of 431 patients with adrenal incidentalomas: retrospective study of a 10-year single-center experience.Turkish journal of medical sciences · 2024Article
- Prevalence of reported incidental adrenal findings in chest computerized tomography scans performed during the COVID-19 pandemic in a single center in Northeast Brazil.Archives of endocrinology and metabolism · 2023Observational
- The Etiological Profile of Adrenal Incidentalomas.Cureus · 2022Article
- A 15-year pheochromocytoma and paraganglioma experience in a single centre: a Singapore perspective.Singapore medical journal · 2022Article
- Pathophysiological Link between Insulin Resistance and Adrenal Incidentalomas.International journal of molecular sciences · 2022Review
- Clinical presentation, management, and research progress of adrenal schwannoma.Frontiers in surgery · 2022Article
- Adrenal myelolipomas.The lancet. Diabetes & endocrinology · 2021Review
- Approach to the Patient With Adrenal Incidentaloma.The Journal of clinical endocrinology and metabolism · 2021Review
- Adrenal Incidentaloma.Endocrine reviews · 2020Review
- Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: a population-based cohort study.The lancet. Diabetes & endocrinology · 2020Article
- Characteristics of adrenocortical carcinoma in South Korea: a registry-based nationwide survey.Endocrine connections · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics of AIs in Korean patients and compared them with those reported in the largest retrospective study in Italy to discover the effects of improved imaging techniques and ethnicity differences. MATERIALS AND
methodsThis was a prospective, multicenter, cross-sectional observational study including 1005 Korean patients. Levels of plasma adrenocorticotrophic hormone, 24-h urinary free cortisol (UFC), serum cortisol after a 1 mg-dexamethasone suppression test, 24-h urinary fractionated metanephrine, and plasma aldosterone and plasma renin activity were measured. All AIs were characterized using computed tomography (CT).
resultsCompared with the results of the Italian study, AIs in Korean patients were observed more frequently in men and predominantly on the left side. Korean patients with AIs were slightly younger, and fewer patients underwent surgery. Most AIs were nonfunctional in both studies, while fewer subclinical hypercortisolism and more primary aldosteronism (PA) cases were detected in Korean patients. In our study, high UFC levels showed very low sensitivity, compared to those in the Italian study. In pheochromocytoma or PA cases, there were no hormonal differences between the studies. AIs in Korean patients were smaller, such that a lower cutoff size for detecting adrenocortical carcinoma (ACC) could be warranted.
conclusionRecent advances in CT technology were leveraged to provide accurate characteristics of AIs and to detect smaller ACCs.
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