ArticleDevelopmental psychobiology2018
Neonatal pain and stress disrupts later-life pavlovian fear conditioning and sensory function in rats: Evidence for a two-hit model.
Article in Developmental psychobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Early-life pain alters excitability of corticotropin-releasing factor-expressing neurons in the central amygdala and stress-induced hypersensitivity during adolescence.Frontiers in behavioral neuroscience · 2025Article
- A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies.Biological psychiatry · 2024Article
- Effects of different types of neonatal pain on somatosensory and cognitive development in male juvenile rats.Brain and behavior · 2023Article
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Neonatal procedural pain affects state, but not trait anxiety behavior in adult rats.Developmental psychobiology · 2021Article
- Amygdalar Corticotropin-Releasing Factor Signaling Is Required for Later-Life Behavioral Dysfunction Following Neonatal Pain.Frontiers in physiology · 2021Article
- Inflammatory neonatal pain disrupts maternal behavior and subsequent fear conditioning in a rodent model.Developmental psychobiology · 2020Article
- Repetitive Pain in Neonatal Male Rats Impairs Hippocampus-Dependent Fear Memory Later in Life.Frontiers in neuroscience · 2020Article
- Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.Frontiers in pediatrics · 2020Review
- Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation.Frontiers in behavioral neuroscience · 2019Article
- Adverse Behavioral Changes in Adult Mice Following Neonatal Repeated Exposure to Pain and Sucrose.Frontiers in psychology · 2018Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Early life trauma has been linked to increased risks for anxiety, depression, and chronic pain. We used rodent models of acute and inflammatory neonatal pain to explore effects on fear conditioning and somatosensory function. Hindpaw needle pricks or handling on postnatal days (PNDs) 1-7 caused lasting impacts on affective and somatosensory function when assessed at later ages, PNDs 24 (postweaning), 45 (adolescence), or 66 (adulthood). First, auditory, but not contextual, freezing was mildly disrupted regardless of age. Second, a profound postfear conditioning tactile hypersensitivity was observed in neonatally stressed, postweaning rats. In the absence of fear conditioning, the mechanical hypersensitivity was not observed, consistent with a two-hit model of psychopathology. Injections of 2% α-carrageenan did not have the same lasting impact but was slightly protective against observed effects of neonatal vehicle injections. Basal and elicited corticosterone levels postweaning were not altered by neonatal pain or handling. These data demonstrate that neonatal adversity can have lasting impacts on affective and somatosensory function that differs regardless of age.
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