Evidence map›Paper›PMID 29748892›Full record

ReviewIrish journal of medical science2019

Updated pharmacological management of rheumatoid arthritis for women before, during, and after pregnancy, reflecting recent guidelines.

Kieran E Murray, Louise Moore, Celine O'Brien, Anne Clohessy, Caroline Brophy, Patricia Minnock, Oliver FitzGerald, Eamonn S Molloy, Anne-Barbara Mongey, Shane Higgins and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Irish journal of medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Benefits and Risks of IgG Transplacental Transfer.Diagnostics (Basel, Switzerland) · 2020
    Review
  5. Fertility and infertility implications in rheumatoid arthritis; state of the art.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kieran E MurrayRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland. kemurray@hotmail.com.ORCID http://orcid.org/0000-0001-6201-8116
Louise MooreRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.
Celine O'BrienUCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Anne ClohessyUCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Caroline BrophyUCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Patricia MinnockRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.
Oliver FitzGeraldRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.
Eamonn S MolloyRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.
Anne-Barbara MongeyRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.
Shane HigginsUCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Mary F HigginsUCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Fionnuala M Mc AuliffeUCD Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Douglas J VealeRheumatic Musculoskeletal Disease Unit, Our Lady's Hospice an Dublin d Care Services, Harold's Cross, Ireland.
University College Dublin · IEOur Lady's Hospital · IESt. Vincent's University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can cause significant disability, morbidity, mortality, and impaired fertility. It commonly affects women of childbearing age. Managing rheumatoid arthritis (RA) in the perinatal period poses challenges. There is concern about the teratogenic effects of many traditional disease-modifying anti-rheumatic drugs (DMARDs) and an ever-growing list of new therapeutic options with limited data in pregnancy and breastfeeding.

aimsWe aimed to create a standardized approach to pharmacological management of RA patients seen in our newly established Rheumatology and Reproductive Health Service.

methodsWe reviewed relevant publications on the use of anti-rheumatic drugs in pregnancy. These include recent guidelines from The British Society for Rheumatology (BSR) and British Health Professionals in Rheumatology (BHPR) and the European League Against Rheumatism (EULAR).

resultsAfter considering relevant publications, we developed a Saint Vincent's University Hospital/National Maternity Hospital consensus protocol for evidence-based medication in pregnancy in RA.

conclusionsRA tends to improve during pregnancy and flare postpartum. Several anti-rheumatic medication options during pregnancy and breastfeeding are now available including anti-tumor necrosis factor (anti-TNF) agents. Good disease control at all stages of reproduction is important to ensure best outcome for both mother and baby.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidBreast FeedingContraindications, DrugFemaleHumansLactationPractice Guidelines as TopicPregnancyPregnancy ComplicationsAntirheumatic AgentsArthritisPeripartumPregnancyRheumatoid arthritisTeratogen

Identifiers

PMID29748892
OpenAlexW2802447347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.