ArticleJAMA1988
The impact of diabetes on survival following myocardial infarction in men vs women. The Framingham Study.
Article in JAMA, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 97 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cyclotron Produced Isotopes in Biology and Medicine, Project 3: Specific Aim 1A and 1B Effects of Fatty Acid Delivery on Myocardial Metabolism and Function in Type 2 Diabetes (T2DM)
Open the trial in the graphQuantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy
IRB #14547: Expression of Angiogenic Factors in Myocardial Tissue in Diabetic and Non-diabetic Patients Undergoing Coronary Bypass Surgery
Who cites it
97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 481 citations in OpenAlex.
- Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021.Frontiers in endocrinology · 2022Pooled it
- Screening for Asymptomatic Coronary Artery DiseaseFrontiers in cardiovascular medicine · 2021Pooled it
- Autonomic neuropathy and survival in diabetes mellitus: effects of pancreas transplantation.Diabetologia · 1991Trial
- Insights Into Cardiovascular Disease in Women From the Framingham Heart Study.JACC. Advances · 2026Article
- The heart of diabetes: unraveling metabolic drivers of cardiomyopathy.Cardiovascular diabetology. Endocrinology reports · 2025Review
- Sex differences in outcomes in patients with acute myocardial infarction.BMC cardiovascular disorders · 2025Article
- Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus.International journal of molecular sciences · 2024Review
- Nomogram for Predicting in-Hospital Severe Complications in Patients with Acute Myocardial Infarction Admitted in Emergency Department.Risk management and healthcare policy · 2024Article
- A bibliometric analysis of acute myocardial infarction in women from 2000 to 2022.Frontiers in cardiovascular medicine · 2023Article
- Case Fatality of Patients With Type 1 Diabetes After Myocardial Infarction.Diabetes care · 2022Article
- Hemoglobin A1C as a prognostic factor and the pre-diabetic paradox in patients admitted to a tertiary care medical center intensive cardiac care unit : The Jerusalem platelets thrombosis and intervention in cardiology (JUPITER-6) study group.Cardiovascular diabetology · 2022Article
- Diabetic Retinopathy and Skin Tissue Advanced Glycation End Products Are Biomarkers of Cardiovascular Events in Type 2 Diabetic Patients.Journal of personalized medicine · 2021Article
- Admission hyperglycemia and all-cause mortality in diabetic and non-diabetic patients with acute myocardial infarction: a tertiary center analysis.Internal and emergency medicine · 2021Article
- The Association Between Baseline Insulin Treatment and Cardiovascular Events: A Meta-Analysis.Journal of the Endocrine Society · 2021Review
- Association of Diabetes Mellitus With Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study.Journal of the American Heart Association · 2019Article
- Insulin resistance and dysglycemia are associated with left ventricular remodeling after myocardial infarction in non-diabetic patients.Cardiovascular diabetology · 2019Article
- Feasibility of neoadjuvant therapy for elderly patients with locally advanced rectal cancer.Surgery today · 2019Article
- Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.International journal of molecular sciences · 2019Review
- A clinical prescription for heart health in midlife women.Maturitas · 2019Review
- Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms.The Canadian journal of cardiology · 2018Review
37 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of diabetes on recurrent myocardial infarction (MI) and fatal coronary heart disease was examined in survivors of an initial MI using 34-year follow-up data in the Framingham Study. Among nondiabetic patients, the risk of fatal coronary heart disease was significantly lower in women compared with men (relative risk, 0.6). In the presence of diabetes, however, the risk of recurrent MI in women was twice the risk in men. In addition, the effect of diabetes doubled the risk of recurrent MI in women (relative risk, 2.1) but had an insignificant effect in men. Increased susceptibility to cardiac failure among diabetic women was an important factor in determining survivorship. Women with diabetes developed cardiac failure four times more often (16%) than women without diabetes (3.8%). Furthermore, when cardiac failure developed, 25% of diabetic women experienced a recurrent MI or fatal coronary event, more than doubling the rate when diabetes was absent. We conclude that in the diabetic patient who survives an MI, cardiac failure is a common occurrence, warranting early detection and vigorous management in periods of convalescence and follow-up. In addition, when cardiac failure appears, control of diabetes assumes added importance, particularly in women, where its effect on survivorship is considerable.
Indexed as
Identifiers
2974889W2023456363What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.