Evidence map›Paper›PMID 29748873›Full record

ArticleBrain structure & function2018

Brain structure mediates the association between height and cognitive ability.

Eero Vuoksimaa, Matthew S Panizzon, Carol E Franz, Christine Fennema-Notestine, Donald J Hagler, Michael J Lyons, Anders M Dale, William S Kremen

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  18. Retinal vasculometry associations with cognition status in UK Biobank.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eero VuoksimaaInstitute for Molecular Medicine Finland, University of Helsinki, P.O. Box 20 (Tukholmankatu 8), 00014, University of Helsinki, Helsinki, Finland. eero.vuoksimaa@helsinki.fi.ORCID http://orcid.org/0000-0002-6534-3667
Matthew S PanizzonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Donald J HaglerDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Michael J LyonsDepartment of Psychology and Brain Sciences, Boston University, Boston, MA, USA.
Anders M DaleDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Archiving the Vietnam Era Twin Studies of Aging (VETSA): New Uses for Old DataR03AG046413 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FRANZ, CAROL ELAINE · 2013 to 2014
$247k
NIA NIH HHS AG050595NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG076838NIA NIH HHS R03 AG 046413NIA NIH HHS R03 AG046413
6 · The paper itself

Abstract

Height and general cognitive ability are positively associated, but the underlying mechanisms of this relationship are not well understood. Both height and general cognitive ability are positively associated with brain size. Still, the neural substrate of the height-cognitive ability association is unclear. We used a sample of 515 middle-aged male twins with structural magnetic resonance imaging data to investigate whether the association between height and cognitive ability is mediated by cortical size. In addition to cortical volume, we used genetically, ontogenetically and phylogenetically distinct cortical metrics of total cortical surface area and mean cortical thickness. Height was positively associated with general cognitive ability and total cortical volume and cortical surface area, but not with mean cortical thickness. Mediation models indicated that the well-replicated height-general cognitive ability association is accounted for by individual differences in total cortical volume and cortical surface area (highly heritable metrics related to global brain size), and that the genetic association between cortical surface area and general cognitive ability underlies the phenotypic height-general cognitive ability relationship.

Indexed as

Body HeightCognitionMagnetic Resonance ImagingTwins, DizygoticTwins, MonozygoticBrainBrain MappingHumansMaleMiddle AgedNeuropsychological TestsPhenotypeCognitive abilityCortical surface areaCortical thicknessHeightMagnetic resonance imagingTwins

Identifiers

PMID29748873
PMCPMC6425087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.