ArticleChemistry Central journal2018
In vitro and in silico studies of terpenes, terpenoids and related compounds with larvicidal and pupaecidal activity against Culex quinquefasciatus Say (Diptera: Culicidae).
Article in Chemistry Central journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Integrated experimental and computational evaluation of Anagallis foemina derived terpenoids against carbapenem resistant Acinetobacter baumannii.Scientific reports · 2026Article
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- QSAR Regression Models for Predicting HMG-CoA Reductase Inhibition.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The Clinical Translation of α-humulene - A Scoping Review.Planta medica · 2024Article
- Antileishmanial natural products as potential inhibitors of theIn silico pharmacology · 2024Article
- Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species.Plants (Basel, Switzerland) · 2023Article
- In vitro and Quantitative and Structure Activity Relationship (QSAR) evaluation of the antifungal activity of terpenoid constituents of essential oils against Alternaria alternata and Fusarium oxysporumBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Terpenic Constituents of Essential Oils with Larvicidal Activity againstMolecules (Basel, Switzerland) · 2023Article
- Differentiation of action mechanisms between natural and synthetic repellents through neuronal electroantennogram and proteomic in Aedes aegypti (Diptera: Culicidae).Scientific reports · 2022Article
- Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents.Molecules (Basel, Switzerland) · 2022Review
- An overview of the chemical composition and biological activities of essential oils fromRSC advances · 2021Review
- The impact of extraction protocol on the chemical profile of cannabis extracts from a single cultivar.Scientific reports · 2021Article
- In Silico and In Vitro Screening of Antipathogenic Properties ofAntibiotics (Basel, Switzerland) · 2021Article
- Acaricidal, Insecticidal, and Nematicidal Efficiency of Essential Oils Isolated from theInternational journal of environmental research and public health · 2021Review
- Differential Antimicrobial Effect of Essential Oils and Their Main Components: Insights Based on the Cell Membrane and External Structure.Membranes · 2021Article
- Piper capitarianum essential oil: a promising insecticidal agent for the management of Aedes aegypti and Aedes albopictus.Environmental science and pollution research international · 2021Article
- Biocontrol Potential of Essential Oils in Organic Horticulture Systems: From Farm to Fork.Frontiers in nutrition · 2021Review
- Essential Oils ofPlants (Basel, Switzerland) · 2020Article
- Essential Oils Extracted from Different Species of the Lamiaceae Plant Family as Prospective Bioagents against Several Detrimental Pests.Molecules (Basel, Switzerland) · 2020Review
- Design of a Repellent Against Aedes aegypti (Diptera: Culicidae) Using in silico Simulations With AaegOBP1 Protein.Journal of medical entomology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIn order to develop new larvicidal agents derived from phytochemicals, the larvicidal activity of fifty molecules that are constituent of essential oils was evaluated against Culex quinquefasciatus Say. Terpenes, terpenoids and phenylpropanoids molecules were included in the in vitro evaluation, and QSAR models using genetic algorithms were built to identify molecular and structural properties of biological interest. Further, to obtain structural details on the possible mechanism of action, selected compounds were submitted to docking studies on sterol carrier protein-2 (SCP-2) as possible target.
resultsResults showed high larvicidal activity of carvacrol and thymol on the third and fourth larval stage with a median lethal concentration (LC
conclusionsThe description of the molecular properties and the structural characteristics responsible for larvicidal activity of the tested compounds were used for the development of mathematical models of structure-activity relationship. The identification of molecular and structural descriptors, as well as studies of molecular docking on the SCP-2 protein, provide insight on the mechanism of action of the active molecules, and the information can be used for the design of new structures for synthesis as potential new larvicidal agents.
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