Evidence map›Paper›PMID 29748717›Full record

ReviewIntensive care medicine2018

Ethical challenges in resuscitation.

Spyros D Mentzelopoulos, Anne-Marie Slowther, Zoe Fritz, Claudio Sandroni, Theodoros Xanthos, Clifton Callaway, Gavin D Perkins, Craig Newgard, Eleni Ischaki, Robert Greif and 2 more

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06245525 (Palliative Care and Legal Aspects of Treatment Limitation Decisions in ICU), which is not on this map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06245525 completednot on this mapstarted 2024, after this paper: background citation

Palliative Care and Legal Aspects of Treatment Limitation Decisions in ICU: A Survey of Clinicians' Perceptions

TypeobservationalSponsorUniversity of AthensRan2024 to 2025Enrolled523ConditionsEnd of LifeArmsThis is not an interventional study
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Non-medical factors in prehospital resuscitation decision-making: a mixed-methods systematic review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2022
    Pooled it
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Spyros D MentzelopoulosFirst Department of Intensive Care Medicine, National and Kapodistrian University of Athens Medical School, Evaggelismos General Hospital, 45-47 Ipsilandou Street, 10675, Athens, Greece. sdmentzelopoulos@yahoo.com.ORCID http://orcid.org/0000-0003-1159-8282
Anne-Marie SlowtherDivision of Health Sciences, Warwick Medical School, Gibbet Hill Campus, Coventry, CV4 7AL, UK.
Zoe FritzAcute Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Claudio SandroniIstituto Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore Fondazione Policlinico, Universitario Agostino Gemelli, Largo Francesco Vito 1, 00168, Rome, Italy.
Theodoros XanthosEuropean University, Engomi, Cyprus.
Clifton CallawayUniversity of Pittsburgh, Pittsburgh, PA, 15260, USA.
Gavin D PerkinsDivision of Health Sciences, Warwick Medical School, Gibbet Hill Campus, Coventry, CV4 7AL, UK.
Craig NewgardDepartment of Emergency Medicine Oregon Health and Science University Portland, Center for Policy and Research in Emergency Medicine, Portland, OR, USA.
Eleni IschakiFirst Department of Intensive Care Medicine, National and Kapodistrian University of Athens Medical School, Evaggelismos General Hospital, 45-47 Ipsilandou Street, 10675, Athens, Greece.
Robert GreifDepartment of Anesthesiology and Pain Therapy, University of Bern, Bern University Hospital, 3010, Bern, Switzerland.
Erwin KompanjeDepartment of Intensive Care, Department of Ethics and Philosophy of Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Leo BossaertFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA rapidly evolving resuscitation science provides more effective treatments to an aging population with multiple comorbidites. Concurrently, emergency care has become patient-centered. This review aims to describe challenges associated with the application of key principles of bioethics in resuscitation and post-resuscitation care; propose actions to address these challenges; and highlight the need for evidence-based ethics and consensus on ethical principles interpretation.

methodsFollowing agreement on the article's outline, subgroups of 2-3 authors provided narrative reviews of ethical issues concerning autonomy and honesty, beneficence/nonmaleficence and dignity, justice, specific practices/circumstances such as family presence during resuscitation, and emergency research. Proposals for addressing ethical challenges were also offered.

resultsRespect for patient autonomy can be realized through honest provision of information, shared decision-making, and advance directives/care planning. Essential prerequisites comprise public and specific healthcare professionals' education, appropriate regulatory provisions, and allocation of adequate resources. Regarding beneficence/nonmaleficence, resuscitation should benefit patients, while avoiding harm from futile interventions; pertinent practice should be based on neurological prognostication and patient/family-reported outcomes. Regarding dignity, aggressive life-sustaining treatments against patients preferences should be avoided. Contrary to the principle of justice, resuscitation quality may be affected by race/income status, age, ethnicity, comorbidity, and location (urban versus rural or country-specific/region-specific). Current evidence supports family presence during resuscitation. Regarding emergency research, autonomy should be respected without hindering scientific progress; furthermore, transparency of research conduct should be promoted and funding increased.

conclusionsMajor ethical challenges in resuscitation science need to be addressed through complex/resource-demanding interventions. Such actions require support by ongoing/future research.

Indexed as

Decision MakingMedical FutilityResuscitationBeneficenceHumansPersonal AutonomyBeneficencePersonal autonomyResuscitationSocial justice

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.