ReviewEuropean journal of clinical nutrition2018
Body composition and cardiometabolic health: the need for novel concepts.
Review in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- The Effects of Online Home-Based Pilates Combined with Diet on Body Composition in Women Affected by Obesity: A Preliminary Study.Nutrients · 2024Trial
- Beyond BMI: Genome-Wide Associations of Visceral Fat, Fat Mass, and Fat-Free Mass in Eastern Asian Populations.Obesity (Silver Spring, Md.) · 2026Article
- Do We Need Body Composition Analysis in Patients with Obesity? A Rethinking of Body Composition Assessment in Preclinical and Clinical Obesity.Obesity facts · 2026Review
- Insulin resistance and metabolic health predict cardiorespiratory fitness: cohort study.European heart journal open · 2026Article
- The role of hepatocyte growth factor in the relationship between body fat distribution and plasma markers of glucose metabolism: a cross-sectional study.Diabetology & metabolic syndrome · 2026Article
- Improving cardiometabolic multimorbidity prediction with a composite obesity-TyG index: a study of middle-aged and older adults in CHARLS.Archives of public health = Archives belges de sante publique · 2025Article
- Total and regional fat-to-muscle mass ratio and risks of pan-cancer: a prospective cohort study.BMC medicine · 2025Article
- The lean body mass to visceral fat mass ratio is negatively associated with cardiometabolic disorders: a cross-sectional study.Scientific reports · 2025Article
- Associations of body size and morphology with cardiometabolic health in children: the contribution of genetic factors.Obesity (Silver Spring, Md.) · 2025Article
- Sex-specific associations between total and regional Fat-to-muscle Mass ratio and cardiometabolic risk: findings from the China National Health Survey.Nutrition journal · 2024Article
- Body composition in second trimester is associated with dyslipidemia in third trimester.Archives of gynecology and obstetrics · 2024Article
- Association of fat-to-muscle mass ratio with physical activity and dietary protein, carbohydrate, sodium, and fiber intake in a cross-sectional study.Scientific reports · 2024Article
- The association between Chinese visceral adiposity index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national cohort study.Frontiers in endocrinology · 2024Article
- Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Patients with Phenylketonuria.Nutrients · 2023Review
- Association of body fat distribution with all-cause and cardiovascular mortality in US adults: a secondary analysis using NHANES.BMJ open · 2023Article
- Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality.Journal of the American Heart Association · 2023Article
- Low Muscle and High Fat Percentages Are Associated with Low Natural Killer Cell Activity: A Cross-Sectional Study.International journal of molecular sciences · 2023Article
- Age-specific and sex-specific associations of visceral adipose tissue mass and fat-to-muscle mass ratio with risk of mortality.Journal of cachexia, sarcopenia and muscle · 2023Article
- Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes.International journal of molecular sciences · 2022Review
- Total and regional fat-to-muscle mass ratio and risks of incident all-cause dementia, Alzheimer's disease, and vascular dementia.Journal of cachexia, sarcopenia and muscle · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It seems reasonable that overweight and obesity should be defined based on body composition rather than indirect indices like BMI or waist circumference. The use of conventional parameters like fat mass or visceral fat is however of similar and limited value for disease risk prediction at the population level and does not contribute much beyond the use of simple BMI or waist circumference. This conundrum may be partly explained by using complex phenotypes (e.g., Metabolic Syndrome or whole body insulin resistance) rather than more disease-specific outcomes like liver- and muscle insulin resistance. In addition, there are multifactorial causes of similar body composition phenotypes that may add to explain the variance in metabolic consequences of these phenotypes. An intriguing hypothesis is that fat mass represents the metabolic load that interacts with fat-free mass that stands for metabolic capacity to determine disease risk. This concept has important implications for assessment of healthy growth and development and when it is challenged with weight gain in adults. Integration of body composition information at the whole body, organ-tissue and cellular level is not required to improve the diagnosis of obesity but facilitates a better understanding of the etiology of obesity-associated metabolic complications.
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