ArticleScientific reports2018
Precocious deposition of perineuronal nets on Parvalbumin inhibitory neurons transplanted into adult visual cortex.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Neonatal Sevoflurane Exposure Induces Long-Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Visual Cortex.bioRxiv : the preprint server for biology · 2025Article
- Neuron-to-glia and glia-to-glia signaling directs critical period experience-dependent synapse pruning.Frontiers in cell and developmental biology · 2025Review
- Topographic Organization of Glutamatergic and GABAergic Parvalbumin-Positive Neurons in the Lateral Habenula.eNeuro · 2024Article
- Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders.International journal of molecular sciences · 2024Review
- Chondroitin 4-Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- LongitudinalNeurophotonics · 2023Article
- Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review.Neurobiology of stress · 2021Review
- Perineuronal Nets in the Prefrontal Cortex of a Schizophrenia Mouse Model: Assessment of Neuroanatomical, Electrophysiological, and Behavioral Contributions.International journal of molecular sciences · 2021Article
- Disruption of rat deep cerebellar perineuronal net alters eyeblink conditioning and neuronal electrophysiology.Neurobiology of learning and memory · 2021Article
- Critical period regulation across multiple timescales.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Shifting Developmental Trajectories During Critical Periods of Brain Formation.Frontiers in cellular neuroscience · 2020Review
- Demystifying the extracellular matrix and its proteolytic remodeling in the brain: structural and functional insights.Cellular and molecular life sciences : CMLS · 2019Review
- Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The end of the critical period for primary visual cortex (V1) coincides with the deposition of perineuronal nets (PNN) onto Parvalbumin (PV) inhibitory neurons. Recently, we found that transplantation of embryonic inhibitory neurons into adult V1 reinstates a new critical period. Here we used Wisteria Floribunda Agglutinin (WFA) staining to compare the deposition of PNNs onto neurons during normal development and following transplantation at equivalent cell ages. In accord with previous findings, PV and PNN expression increases from negligible levels at postnatal day 14 (P14) to mature levels by P70. In contrast to P14, PNNs are found on transplanted PV neurons by 21 days after transplantation and persist to 105 days after transplantation. This precocious deposition was specific to PV neurons and excluded transplanted neurons expressing Somatostatin. Notably, the onset of PV expression in transplanted inhibitory neurons follows the timing of PV expression in juvenile V1. Moreover, transplantation has no discernible effect on host PNNs. The precocious deposition of PNNs onto transplanted PV neurons suggests that PNN expression identified by WFA does not reflect neuronal maturity and may be an inaccurate marker for transplant-induced plasticity of cortical circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.