ArticleNature communications2018
Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed.
- Stimuli-Responsive Aggregation-Induced Emission Materials for Tumor Theranostics: Design Strategies and Biomedical Applications.Small science · 2026Review
- Boosting Red Room-Temperature Phosphorescence by Host-Guest Confinement: Acrylonitrile Derivatives in PMMA Toward Long-Lived Afterglow and Anti-Counterfeiting.Luminescence : the journal of biological and chemical luminescence · 2026Article
- From Spark to Flame: ROS- and Light-Cascade Activatable NIR-II AIE Probe for Precise Tumor Imaging and Self-Amplifying Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Hypoxia-Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High-Specificity Cancer Phototherapy.Angewandte Chemie (International ed. in English) · 2025Article
- Supramolecular Synthesis of Dithienylethene-Albumin Complexes for Enhanced Photoswitching In Photoacoustic Imaging-Guided Near-Infrared Photothermal Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Mini Review On: The Roles of DNA Nanomaterials in Phototherapy.International journal of nanomedicine · 2025Review
- A hypoxia-activated and microenvironment-remodeling nanoplatform for multifunctional imaging and potentiated immunotherapy of cancer.Nature communications · 2024Article
- All-Visible-Light-Activated Diarylethene Photoswitches.Molecules (Basel, Switzerland) · 2024Review
- Smart molecular probes with controllable photophysical property for smart medicine.Smart molecules : open access · 2024Review
- Polymeric Nanoparticles for Drug Delivery.Chemical reviews · 2024Review
- Photoswitching the fluorescence of nanoparticles for advanced optical applications.Chemical science · 2024Review
- A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer's disease.Nature communications · 2024Article
- Dual/Multi-Modal Image-Guided Diagnosis and Therapy Based on Luminogens with Aggregation-Induced Emission.Molecules (Basel, Switzerland) · 2024Review
- Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles.Nature communications · 2023Article
- A route to metalloligands consolidated silver nanoclusters by grafting thiacalix[4]arene onto polyoxovanadates.Nature communications · 2023Article
- A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy.Nature communications · 2023Article
- Light-regulating chirality of metallacages featuring dithienylethene switches.Chemical science · 2023Article
- Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential.Bioactive materials · 2023Review
- Ligand engineering of AuChemical science · 2023Article
- Rational Design of High-Performance Hemithioindigo-Based Photoswitchable AIE Photosensitizer and Enabling Reversible Control Singlet Oxygen Generation.Biosensors · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM). The photosensitive molecule changes from a ring-closed, for photoacoustic imaging, to a ring-opened state for fluorescence and photodynamic effects upon an external light trigger. The nanoparticles' photoacoustic and fluorescence imaging properties demonstrate the advantage of the switch. The use of the nanoparticles improves the outcomes of in vivo cancer surgery using preoperative photoacoustic imaging and intraoperative fluorescent visualization/photodynamic therapy of residual tumours to ensure total tumour removal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.