Evidence map›Paper›PMID 29748506›Full record

ReviewNutrients2018

Dietary Neurotransmitters: A Narrative Review on Current Knowledge.

Matteo Briguglio, Bernardo Dell'Osso, Giancarlo Panzica, Antonio Malgaroli, Giuseppe Banfi, Carlotta Zanaboni Dina, Roberta Galentino, Mauro Porta

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
25.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
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  12. Review
  13. Article
  14. Human gut microbiome, diet, and mental disorders.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Review
  15. Review
  16. Fermented foods and gastrointestinal health: underlying mechanisms.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Matteo BriguglioTourette's Syndrome and Movement Disorders Centre, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy. docmatteobriguglio@gmail.com.ORCID 0000-0003-0801-2359
Bernardo Dell'OssoDepartment of Pathophysiology and Transplantation, I.R.C.C.S. Ca' Granda Foundation, Ospedale Maggiore Policlinico, 20122 Milan, Italy. bernardo.dellosso@policlinico.mi.it.
Giancarlo PanzicaDepartment of Neuroscience, Rita Levi Montalcini, University of Turin, 10126 Turin, Italy. giancarlo.panzica@unito.it.ORCID 0000-0002-9302-4647
Antonio MalgaroliNeurobiology of Learning Unit, Division of Neuroscience, Vita-Salute San Raffaele University, 20132 Milan, Italy. malgaroli.antonio@unisr.it.
Giuseppe BanfiScientific Direction, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy. banfi.giuseppe@fondazionesanraffaele.it.
Carlotta Zanaboni DinaTourette's Syndrome and Movement Disorders Centre, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy. carlotta.zanaboni@libero.it.
Roberta GalentinoTourette's Syndrome and Movement Disorders Centre, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy. roberta.galentino@gmail.com.
Mauro PortaTourette's Syndrome and Movement Disorders Centre, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy. mauroportamilano@gmail.com.
Istituto Ortopedico Galeazzi · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Turin · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs. Relevant books and literature from PubMed and Scopus databases were searched for data on food sources of Ach, glutamate, GABA, dopamine, 5-HT, and histamine. Different animal foods, fruits, edible plants, roots, and botanicals were reported to contain NTs. These substances can either be naturally present, as part of essential metabolic processes and ecological interactions, or derive from controlled/uncontrolled food technology processes. Ripening time, methods of preservation and cooking, and microbial activity further contributes to NTs. Moreover, gut microbiota are considerable sources of NTs. However, the significance of dietary NTs intake needs to be further investigated as there are no significant data on their bioavailability, neuronal/non neuronal effects, or clinical implications. Evidence-based interventions studies should be encouraged.

Indexed as

DietAcetylcholineBiogenic AminesDopamineFood Analysisgamma-Aminobutyric AcidGlutamic AcidHistamineHumansNeuronsNeurotransmitter AgentsSerotoninAcetylcholineBiogenic AminesDopaminegamma-Aminobutyric AcidGlutamic AcidHistamineNeurotransmitter AgentsSerotoninacetylcholinediet, food, and nutritiondopaminefunctional foodsgamma-aminobutyric acidglutamategut microbiotahistamineneurotransmittersserotonin

Identifiers

PMID29748506
PMCPMC5986471
OpenAlexW2799631956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.