Evidence map›Paper›PMID 29748487›Full record

ArticleBiomolecules2018

Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State.

Anna Lappala, Wataru Nishima, Jacob Miner, Paul Fenimore, Will Fischer, Peter Hraber, Ming Zhang, Benjamin McMahon, Chang-Shung Tung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Modeling theBiomolecules · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anna LappalaLos Alamos National Laboratory, Los Alamos, NM 87545, USA. vernon.anna@cantab.net.ORCID 0000-0001-9926-2972
Wataru NishimaLos Alamos National Laboratory, Los Alamos, NM 87545, USA. w.nishima@lanl.gov.
Jacob MinerLos Alamos National Laboratory, Los Alamos, NM 87545, USA. jcminer@lanl.gov.ORCID 0000-0002-5600-5252
Paul FenimoreLos Alamos National Laboratory, Los Alamos, NM 87545, USA. paulf@lanl.gov.
Will FischerLos Alamos National Laboratory, Los Alamos, NM 87545, USA. wfischer@lanl.gov.ORCID 0000-0003-4579-4062
Peter HraberLos Alamos National Laboratory, Los Alamos, NM 87545, USA. phraber@lanl.gov.ORCID 0000-0002-2920-4897
Ming ZhangCollege of Public Health, University of Georgia, Athens, GA 30602, USA. mzhang01@uga.edu.
Benjamin McMahonLos Alamos National Laboratory, Los Alamos, NM 87545, USA. mcmahon@lanl.gov.
Chang-Shung TungLos Alamos National Laboratory, Los Alamos, NM 87545, USA. ct@lanl.gov.
Los Alamos National Laboratory · USUniversity of Georgia · US

Funding

NIAID NIH HHS HHSN272201400004C
6 · The paper itself

Abstract

Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral genomes and disease etiology, many fusion proteins are arranged as trimers. Structural information for both pre-fusion and fusion-initiation states is critical for understanding virus neutralization by the host immune system. In the case of Ebola virus glycoprotein (EBOV GP) and Zika virus envelope protein (ZIKV E), pre-fusion state structures have been identified experimentally, but only partial structures of fusion-initiation states have been described. While the fusion-initiation structure is in an energetically unfavorable state that is difficult to solve experimentally, the existing structural information combined with computational approaches enabled the modeling of fusion-initiation state structures of both proteins. These structural models provide an improved understanding of four different neutralizing antibodies in the prevention of viral host entry.

Indexed as

Virus InternalizationAntibodies, ViralEbolavirusMolecular Dynamics SimulationProtein BindingViral Envelope ProteinsZika VirusAntibodies, Viralenvelope glycoprotein, Ebola virusViral Envelope Proteinsantibody bindingEBOV GPpre-fusion-to-fusion transitionZIKV E

Identifiers

PMID29748487
PMCPMC6022868
OpenAlexW2789255866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.