Evidence map›Paper›PMID 29748438›Full record

ArticleHaematologica2018

Outcomes of hematopoietic stem cell transplantation from unmanipulated haploidentical versus matched sibling donor in patients with acute myeloid leukemia in first complete remission with intermediate or high-risk cytogenetics: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Dalila Salvatore, Myriam Labopin, Annalisa Ruggeri, Giorgia Battipaglia, Ardeshir Ghavamzadeh, Fabio Ciceri, Didier Blaise, William Arcese, Gerard Sociè, Jean Henri Bourhis and 7 more

Abstract read
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
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  7. Trial
  8. Outcomes of Haploidentical Transplantation in Patients with Relapsed Multiple Myeloma: An EBMT/CIBMTR Report.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Managing Invasive Fungal Infections During Allogeneic Hematopoietic Transplantation: A 2025 Update.Mediterranean journal of hematology and infectious diseases · 2025
    Review
  14. Quality-adjusted time without symptoms or toxicity analysis of haploidentical-related donorChinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Dalila SalvatoreService d'Hématologie et Thérapie Cellulaire Hôpital Saint Antoine, Paris, France.
Myriam LabopinService d'Hématologie et Thérapie Cellulaire Hôpital Saint Antoine, Paris, France.
Annalisa RuggeriService d'Hématologie et Thérapie Cellulaire Hôpital Saint Antoine, Paris, France annalisaruggeri80@hotmail.com.
Giorgia BattipagliaService d'Hématologie et Thérapie Cellulaire Hôpital Saint Antoine, Paris, France.
Ardeshir GhavamzadehShariati Hospital, Hematology-Oncology and BMT Research, Teheran, Iran.
Fabio CiceriHaematology and BMT Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
Didier BlaiseProgramme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, France.
William ArceseStem Cell Transplant Unit, Policlinico Universitario Tor Vergata, Rome, Italy.
Gerard SocièHopital St. Louis, Dept.of Hematology - BMT, Paris, France.
Jean Henri BourhisHematology department, Institut Gustave Roussy, Villejuif, France.
Maria Teresa Van LintOspedale San Martino, Department of Haematology II Genova.
Benedetto BrunoA.O.U. Città della Salute e della Scienza, Torino, Italy.
Anne HuynhInstitut Universitaire du Cancer Toulouse, Oncopole, France.
Stella SantaroneUnità Terapia Intensiva Ematologica per il Trapianto Emopoietico, Ospedale Civile, Pescara, Italia.
Eric DeconinckHopital Jean Minjoz, Service d'Hématologie, Besançon, France.
Mohamad MohtyService d'Hématologie et Thérapie Cellulaire Hôpital Saint Antoine, Paris, France.
Arnon NaglerAcute Leukemia Working Party of EBMT, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation is the optimal care for patients with high-risk or intermediate - acute myeloid leukemia. In patients lacking matched sibling donor, haploidentical donors are an option. We compared outcomes of unmanipulated (Haplo) to matched sibling donor transplant in acute myeloid leukemia patients in first complete remission. Included were intermediate and high-risk acute myeloid leukemia in first complete remission undergoing Haplo and matched sibling donor transplant from 2007-2015, and reported to the ALWP of the EBMT. A propensity score technique was used to confirm results of main analysis: 2 matched sibling donors were matched with 1 Haplo. We identified 2654 pts (Haplo =185; matched sibling donor =2469), 2010 with intermediate acute myeloid leukemia (Haplo=122; matched sibling donor =1888) and 644 with high-risk acute myeloid leukemia (Haplo =63; matched sibling donor =581). Median follow up was 30 (range 1-116) months. In multivariate analysis, in intermediate - acute myeloid leukemia patients, Haplo resulted in lower leukemia-free survival (Hazard Ratio 1.74;

Indexed as

Tissue DonorsAdolescentAdultAgedCytogeneticsFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteMaleMiddle AgedRemission InductionRetrospective StudiesRisk AssessmentSiblings

Identifiers

PMID29748438
PMCPMC6068036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.