ArticleScience (New York, N.Y.)2018
Structural basis for recognition of frizzled proteins by
Open access · bronzeAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 128 citations in OpenAlex.
- Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota.Antimicrobial agents and chemotherapy · 2019Trial
- From colonization to infection: Genomic evolution of Clostridioides difficile pathogenesis.Cell reports · 2026Review
- The impact of TcdB conformational dynamics on vaccination against Clostridioides difficile.PLoS pathogens · 2026Article
- A multifunctional probiotic co-delivery platform for the treatment of Clostridium difficile infection.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Immune Aspects of Clostridioides difficile Infection and Vaccine Development.Infectious disease clinics of North America · 2025Review
- CD44 is a macrophage receptor for TcdB fromGut microbes · 2025Article
- Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin.Nature microbiology · 2025Article
- Biliverdin targeting TcdB-DRBD inhibits Clostridioides difficile virulence and restores gut microbiota in Mongolian gerbils (Meriones unguiculatus).Communications biology · 2025Article
- Mouse monoclonal antibodies againstInfection and immunity · 2025Article
- De novo design of potent inhibitors of clostridial family toxins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Research progress and challenges of molecular recognition techniques in the screening of active ingredients in Traditional Chinese medicine.Journal of pharmaceutical analysis · 2025Review
- The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection.Nature reviews. Gastroenterology & hepatology · 2025Review
- The scramblases VMP1 and TMEM41B are required for primitive endoderm specification by targeting WNT signaling.Cell death and differentiation · 2025Article
- MappingmBio · 2025Article
- Mechanisms ofFrontiers in cellular and infection microbiology · 2025Review
- Structure-based drug design with equivariant diffusion models.Nature computational science · 2024Article
- De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants.Nature communications · 2024Article
- Structural insights into Frizzled3 through nanobody modulators.Nature communications · 2024Article
- A sequence invariable region in TcdB2 is required for toxin escape fromJournal of bacteriology · 2024Article
- Genomic and phenotypic studies amongMicrobiology spectrum · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Peng ChenDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-6356-7683
Liang TaoDepartment of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3441-698X
Tianyu WangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Jie ZhangDepartment of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Aina HeDepartment of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA, USA.
Kwok-Ho LamDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-7173-6600
Zheng LiuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
Xi HeF. M. Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA, USA.
Kay PerryNE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Argonne, IL, USA.ORCID 0000-0002-4046-1704
Min DongDepartment of Urology, Boston Children's Hospital, Department of Microbiology and Immunobiology and Department of Surgery, Harvard Medical School, Boston, MA, USA. r.jin@uci.edu min.dong@childrens.harvard.edu.ORCID 0000-0002-1744-7293
Rongsheng JinDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA. r.jin@uci.edu min.dong@childrens.harvard.edu.ORCID 0000-0003-0348-7363
Boston Children's Hospital · USUniversity of California, Irvine · USArgonne National Laboratory · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MOverall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3MLong-term effects of botulinum neurotoxins on neuronal viabilityR01NS080833 · NINDS · HARVARD MEDICAL SCHOOL · PI Min Dong · 2013 to 2026
$6.8MWnt-LRP interaction in Wnt signal transductionR01GM057603 · NIGMS · CHILDREN'S HOSPITAL BOSTON · PI HE, XI · 1999 to 2018
$6.3MMolecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI DONG, MIN · 2017 to 2021
$3.5MMolecular mechanisms of botulinum neurotoxin neutralizationR01AI125704 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG, SHOEMAKER, CHARLES BIX · 2016 to 2020
$3.0MStructural and functional studies of botulinum neurotoxinR01AI091823 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2012 to 2016
$2.0MPixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8MNovel regulators of Wnt/R-spondin signaling in early vertebrate embryogenesisR01GM126120 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI HE, XI · 2018 to 2019
$794kStructural mechanism for recognition of host receptor by botulinum neurotoxin AR21AI123920 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI JIN, RONGSHENG · 2016 to 2017
$425kNCRR NIH HHS S10 RR029205NIAID NIH HHS R01 AI091823NIAID NIH HHS R01 AI125704NIAID NIH HHS R01 AI132387NIAID NIH HHS R21 AI123920NICHD NIH HHS P30 HD018655NIDDK NIH HHS P30 DK034854NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM057603NIGMS NIH HHS R01 GM126120NINDS NIH HHS R01 NS080833
Abstract
PubMed holds no abstract for this paper.
Indexed as
Bacterial ProteinsBacterial ToxinsBinding SitesClostridioides difficileClostridium InfectionsCrystallography, X-RayFatty AcidsFrizzled ReceptorsHumansProtein DomainsVirulence FactorsWnt Signaling PathwayBacterial ProteinsBacterial ToxinsFatty AcidsFrizzled ReceptorsFZD2 protein, humantoxB protein, Clostridium difficileVirulence Factors
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.