ArticleScience (New York, N.Y.)2018
An anatomic transcriptional atlas of human glioblastoma.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 407 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
407citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
407 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Three Pillars of Glioblastoma: A Systematic Review and Novel Analysis of Multi-Omics and Clinical Data.Cells · 2024Pooled it
- L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial.Nature communications · 2026Trial
- Integrated Genetic Screening Identifies FEN1 as a Selective Vulnerability and Temozolomide Resistance Mediator in Glioblastoma Stem Cells.Cancer research communications · 2026Article
- Integrative transcriptomic, spatial and functional-genomic analysis identifies a UFMylation-related vascular-stromal program and prioritizes WWTR1 in glioblastoma.Functional & integrative genomics · 2026Article
- Multi-sampling allows intra-tumoral heterogeneity querying and vulnerability profiling in glioblastoma.Neuro-oncology · 2026Article
- FAPExperimental & molecular medicine · 2026Article
- Accurate prediction in reconstructed spatial transcriptomes does not ensure valid biological discovery.bioRxiv : the preprint server for biology · 2026Article
- Article
- Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma.Journal of neuroinflammation · 2026Article
- IL6 Supports Development of an Immunosuppressive Microenvironment and Resistance to Therapy in Glioblastoma.Cancer research · 2026Article
- Spatial and multi-omic profiling reveals pericyte-derived CCL19 as a key prognostic factor in CNS lymphoma.HemaSphere · 2026Article
- Article
- Integrative Multi-Omics Analysis Identifies anGenes · 2026Article
- Copper transporters promote the malignant progression of glioblastoma by regulating the immunosuppressive tumour microenvironment via the SLC31A1-WNT5A axis.Journal of translational medicine · 2026Article
- Glioblastoma: epidemiology, molecular pathogenesis, diagnosis, management, and therapeutic resistance.Molecular biomedicine · 2026Review
- An EGFR co-amplified lncRNA HELDR promotes glioblastoma malignancy through KAT7-driven gene programs.Nature cell biology · 2026Article
- Article
- Metabolic profiling defines glioblastoma subtypes with distinct prognoses and therapeutic vulnerabilities.Neuro-oncology · 2026Article
- Targeting WTAP/ROR1/WNT5A-Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
347 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
80 authors.
Ralph B PuchalskiAllen Institute for Brain Science, Seattle, WA 98109, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.ORCID 0000-0002-9267-0575
Nameeta ShahBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.ORCID 0000-0002-4429-8414
Jeremy MillerAllen Institute for Brain Science, Seattle, WA 98109, USA.
Rachel DalleyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Steve R NomuraBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0002-2729-4083
Jae-Guen YoonBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0001-6748-2970
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA 98109, USA.
Michael LankerovichBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0001-9475-8346
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-6626-1567
Kris BickleyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-2828-4282
Andrew F BoeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Krissy BrounerAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5790-7154
Stephanie ButlerAllen Institute for Brain Science, Seattle, WA 98109, USA.
Shiella CaldejonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Mike ChapinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-7642-1539
Suvro DattaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Nick DeeAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-2831-9254
Tsega DestaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-0858-2191
Tim DolbeareAllen Institute for Brain Science, Seattle, WA 98109, USA.
Nadezhda DotsonAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-3414-3176
Amanda EbbertAllen Institute for Brain Science, Seattle, WA 98109, USA.
David FengAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4920-8123
Xu FengRadia Inc., Lynnwood, WA 98036, USA.ORCID 0000-0001-7795-3756
Michael FisherAllen Institute for Brain Science, Seattle, WA 98109, USA.
Garrett GeeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jeff GoldyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-5140-6922
Lindsey GourleyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Benjamin W GregorAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-9205-801X
Guangyu GuAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9884-150X
Nika HejaziniaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-0365-7062
John HohmannAllen Institute for Brain Science, Seattle, WA 98109, USA.
Parvinder HothiBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Robert HowardAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kevin JoinesAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-2340-4369
Ali KriedbergAllen Institute for Brain Science, Seattle, WA 98109, USA.
Leonard KuanAllen Institute for Brain Science, Seattle, WA 98109, USA.
Chris LauAllen Institute for Brain Science, Seattle, WA 98109, USA.
Felix LeeAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-3919-3271
Hwahyung LeeBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Tracy LemonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Fuhui LongAllen Institute for Brain Science, Seattle, WA 98109, USA.
Naveed MastanAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-8819-0835
Erika MottAllen Institute for Brain Science, Seattle, WA 98109, USA.
Chantal MurthyBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.ORCID 0000-0002-7457-4125
Kiet NgoAllen Institute for Brain Science, Seattle, WA 98109, USA.
Eric OlsonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Melissa RedingAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9845-1827
Zack RileyAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-1905-1671
David RosenAllen Institute for Brain Science, Seattle, WA 98109, USA.
David SandmanAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-6968-4859
Nadiya ShapovalovaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-8618-8272
Clifford R SlaughterbeckAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0003-2789-9071
Andrew SodtAllen Institute for Brain Science, Seattle, WA 98109, USA.
Graham StockdaleAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-9871-8904
Aaron SzaferAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-0019-8470
Wayne WakemanAllen Institute for Brain Science, Seattle, WA 98109, USA.
Paul E WohnoutkaAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-4458-623X
Steven J WhiteWhite Marsh Forests, Seattle, WA 98119, USA.ORCID 0000-0002-6357-5472
Don MarshWhite Marsh Forests, Seattle, WA 98119, USA.ORCID 0000-0001-5633-8711
Robert C RostomilyDepartment of Neurosurgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA 98109, USA.
Chinh DangAllen Institute for Brain Science, Seattle, WA 98109, USA.
Allan JonesAllen Institute for Brain Science, Seattle, WA 98109, USA.
Bart KeoghRadia Inc., Lynnwood, WA 98036, USA.
Haley R GittlemanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.ORCID 0000-0001-6190-9304
Patrick J CiminoDepartment of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.ORCID 0000-0003-0441-4502
Megha S UppinNizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500082, India.
C Dirk KeeneDepartment of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.ORCID 0000-0002-5291-1469
Farrokh R FarrokhiVirginia Mason Medical Center, Seattle, WA 98101, USA.ORCID 0000-0002-7559-3934
Justin D LathiaDepartment of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
Michael E BerensTGen, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.ORCID 0000-0002-3382-6787
Antonio IavaroneInstitute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
Amy BernardAllen Institute for Brain Science, Seattle, WA 98109, USA.
Ed LeinAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9012-6552
John W PhillipsAllen Institute for Brain Science, Seattle, WA 98109, USA.
Steven W RostadCellNetix, Seattle, WA 98122, USA.ORCID 0000-0002-2935-7391
Charles CobbsBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, WA 98109, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.ORCID 0000-0002-5741-8024
Greg D FoltzBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
Funding
Topology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4MComputational analysis of Human High Grade GliomasR01NS061776 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO · 2009 to 2013
$2.4MIdentification and modeling of driver genetic modules in glioblastomaR01CA179044 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2014 to 2018
$2.3MThe role of the LZTR1 ubiquitin ligase in stem cells and cancerR01CA190891 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO · 2015 to 2019
$1.9MThe mechanisms driving brain oncogenesis by FGFR-TACC gene fusionsR01CA178546 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO · 2014 to 2018
$1.8MTherapeutically relevant targets of Twist1 dimers in gliomaR01NS091251 · NINDS · UNIVERSITY OF WASHINGTON · PI ROSTOMILY, ROBERT C · 2015 to 2020
$1.8MTWIST1 as a target for inhibition of glioma invasionR01CA136808 · NCI · UNIVERSITY OF WASHINGTON · PI ROSTOMILY, ROBERT C · 2011 to 2015
$1.7MNCI NIH HHS R01 CA136808NCI NIH HHS R01 CA178546NCI NIH HHS R01 CA179044NCI NIH HHS R01 CA190891NCI NIH HHS U54 CA193313NINDS NIH HHS R01 NS061776NINDS NIH HHS R01 NS091251
Abstract
Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.
Indexed as
Atlases as TopicBrain NeoplasmsDatabases, GeneticGene Expression ProfilingGlioblastomaHumansPrognosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.