ArticleScience (New York, N.Y.)2018
Metabolic regulation of transcription through compartmentalized NAD
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.
0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 230 citations in OpenAlex.
- ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesis and fatty acid oxidation in colorectal cancer.bioRxiv : the preprint server for biology · 2026Article
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- ROS-ATM-CBP axis-mediated PARP1 lactylation aggravates doxorubicin-induced cardiotoxicity.Clinical and translational medicine · 2026Article
- SOCS3 Stabilizes PARP1 to Suppress Adipogenic Transcription and Abdominal Adipogenesis in Avian.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Synthesis, Characterization, and Fluorescence Application of Indole-Based Isofunctional NADChembiochem : a European journal of chemical biology · 2026Article
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Nicotinamide mononucleotide enhances anti-tumor effect by resetting macrophages toward the inflammatory M1-like phenotype.Molecular therapy. Oncology · 2026Article
- Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.Tumour virus research · 2026Article
- dCas9-metabolic enzyme fusions modulate global and locus-specific gene expression.bioRxiv : the preprint server for biology · 2026Article
- Nicotinamide mononucleotide attenuates hepatic endoplasmic reticulum stress and modulates circadian rhythms in young mice with diet-induced obesity.Nutrition research and practice · 2026Article
- Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics.The FEBS journal · 2026Article
- NADCell reports · 2026Article
- Aerobic exercise combined with FK866 ameliorates Alzheimer's disease-like pathology in APP/PS1 mice with NAMPT abnormality.Frontiers in immunology · 2026Article
- SRY mediates male-specific susceptibility to acute liver injury.Cell communication and signaling : CCS · 2025Article
- PARP inhibition augments immunomodulatory function of mesenchymal stem/stromal cells by promoting STAT1 phosphorylation.Stem cell research & therapy · 2025Article
- NADNature metabolism · 2025Review
- The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology.International journal of molecular sciences · 2025Review
- Review
- A pH-Centric Model of Nucleolar Activity and Regulation.Journal of molecular biology · 2025Review
- Regulation of adipogenesis by nucleotides.Biochemical Society transactions · 2025Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Keun Woo RyuLaboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-3918-8472
Tulip NanduLaboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9786-614X
Jiyeon KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-0138-1920
Sridevi ChallaLaboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-5308-9243
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2705-7432
W Lee KrausLaboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. lee.kraus@utsouthwestern.edu.ORCID 0000-0002-8786-2986
The University of Texas Southwestern Medical Center · USChildren's Medical Center · US
Funding
Dose-Dependent Effects of Hormone on the Activity of Estrogen Receptor Enhancers and Target GenesR01DK058110 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI WILLIAM Lee KRAUS · 2000 to 2026
$10.4MMetabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MThe Role of PARP-1 in Hormone-Regulated TranscriptionR01DK069710 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KRAUS, WILLIAM LEE · 2004 to 2025
$7.9MMETABOLIC REGULATORS OF TUMOR CELL GROWTHR01CA157996 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DEBERARDINIS, RALPH J · 2011 to 2017
$2.2MHoward Hughes Medical InstituteNCI NIH HHS R01 CA157996NCI NIH HHS R35 CA220449NIDDK NIH HHS R01 DK058110NIDDK NIH HHS R01 DK069710
Abstract
NAD
Indexed as
Transcription, GeneticAdipocytesAdipogenesisAnimalsCCAAT-Enhancer-Binding Protein-betaCell Line, TumorCell NucleusCytoplasmGlucoseHumansMiceNADNicotinamide-Nucleotide AdenylyltransferaseNIH 3T3 CellsPoly (ADP-Ribose) Polymerase-1Substrate SpecificityCCAAT-Enhancer-Binding Protein-betaGlucoseNADNicotinamide-Nucleotide AdenylyltransferaseNMNAT1 protein, humanNMNAT2 protein, humanNMNAT3 protein, humanPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.