ArticleAJNR. American journal of neuroradiology2018
Cerebral Perfusion Is Perturbed by Preterm Birth and Brain Injury.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Neonatal encephalopathy: a diffusional kurtosis imaging analysis of white matter to assess injury severity and recovery.Pediatric research · 2026Article
- Towards quantitative assessment of cerebrovascular autoregulation in human neonates using ultrafast ultrasound imaging.Scientific reports · 2025Article
- Article
- Cerebral blood flow patterns in preterm and term neonates assessed with pseudo-continuous arterial spin labeling perfusion MRI.Human brain mapping · 2023Article
- Article
- Cerebral superb microvascular imaging in preterm neonates: in vivo evaluation of thalamic, striatal, and extrastriatal angioarchitecture.Neuroradiology · 2021Observational
- Longitudinal Trajectories of Regional Cerebral Blood Flow in Very Preterm Infants during Third Trimester Ex Utero Development Assessed with MRI.Radiology · 2021Article
- Regional impairment of cortical and deep gray matter perfusion in preterm neonates with low-grade germinal matrix-intraventricular hemorrhage: an ASL study.Neuroradiology · 2020Observational
- QUEST MRI assessment of fetal brain oxidative stress in utero.NeuroImage · 2019Article
- Altered grey matter volume, perfusion and white matter integrity in very low birthweight adults.NeuroImage. Clinical · 2019Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeEarly disturbances in systemic and cerebral hemodynamics are thought to mediate prematurity-related brain injury. However, the extent to which CBF is perturbed by preterm birth is unknown. Our aim was to compare global and regional CBF in preterm infants with and without brain injury on conventional MR imaging using arterial spin-labeling during the third trimester of ex utero life and to examine the relationship between clinical risk factors and CBF. MATERIALS AND
methodsWe prospectively enrolled preterm infants younger than 32 weeks' gestational age and <1500 g and performed arterial spin-labeling MR imaging studies. Global and regional CBF in the cerebral cortex, thalami, pons, and cerebellum was quantified. Preterm infants were stratified into those with and without structural brain injury. We further categorized preterm infants by brain injury severity: moderate-severe and mild.
resultsWe studied 78 preterm infants: 31 without brain injury and 47 with brain injury (29 with mild and 18 with moderate-severe injury). Global CBF showed a borderline significant increase with increasing gestational age at birth (
conclusionsWe report early disturbances in global and regional CBF in preterm infants following brain injury. Regional cerebral perfusion alterations were evident in the thalamus and pons, suggesting regional vulnerability of the developing cerebro-cerebellar circuitry.
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