Evidence map›Paper›PMID 29748195›Full record

Trial reportCirculation. Arrhythmia and electrophysiology2018

Does High-Intensity Endurance Training Increase the Risk of Atrial Fibrillation? A Longitudinal Study of Left Atrial Structure and Function.

Mildred A Opondo, Norman Aiad, Matthew A Cain, Satyam Sarma, Erin Howden, Douglas A Stoller, Jason Ng, Pieter van Rijckevorsel, Michinari Hieda, Takashi Tarumi and 2 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02039154 (The Effect of Long Duration Exercise on the Diastolic Function of the Heart), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02039154 nacompletednot on this map

The Effect of Long Duration Exercise on the Diastolic Function of the Heart

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2012 to 2016Enrolled61ConditionsAgingArmsAerobic and strength training group, Balance and flexibility group
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mildred A OpondoInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (M.A.O., N.A., M.A.C., S.S., E.H., D.A.S., P.v.R., M.H., T.T., M.D.P., B.D.L.).
Norman AiadDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
Matthew A CainDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
Satyam SarmaDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
Erin HowdenDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
Douglas A StollerDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
Jason NgDepartment of Medicine, University of Illinois at Chicago (J.N.).
Pieter van RijckevorselInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (M.A.O., N.A., M.A.C., S.S., E.H., D.A.S., P.v.R., M.H., T.T., M.D.P., B.D.L.).
Michinari HiedaDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
Takashi TarumiDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.).
M Dean PalmerInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (M.A.O., N.A., M.A.C., S.S., E.H., D.A.S., P.v.R., M.H., T.T., M.D.P., B.D.L.).
Benjamin D LevineDivision of Cardiology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas (N.A., M.A.C., S.S., E.H., D.A.S., M.H., T.T., B.D.L.). BenjaminLevine@TexasHealth.org.
Institute for Exercise and Environmental Medicine · USCardiovascular Institute of the South · USUniversity of Illinois Chicago · US

Funding

Aging Fitness & Failure: Mechanisms of Diastolic DysfunctionR01AG017479 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BENJAMIN D · 2001 to 2016
$7.8M
NIA NIH HHS R01 AG017479
6 · The paper itself

Abstract

backgroundExercise mitigates many cardiovascular risk factors associated with atrial fibrillation. Endurance training has been associated with atrial structural changes which can increase the risk for atrial fibrillation. The dose of exercise training required for these changes is uncertain. We sought to evaluate the impact of exercise on left atrial (LA) mechanical and electrical function in healthy, sedentary, middle-aged adults.

methodsSixty-one adults (52±5 years) were randomized to either 10 months of high-intensity exercise training or yoga. At baseline and post-training, all participants underwent maximal exercise stress testing to assess cardiorespiratory fitness, P-wave signal-averaged electrocardiography for filtered P-wave duration and atrial late potentials (root mean square voltage of the last 20 ms), and echocardiography for LA volume, left ventricular end-diastolic volume, and mitral inflow for assessment of LA active emptying. Post-training data were compared with 14 healthy age-matched Masters athletes.

resultsLA volume, Vo

conclusionsChanges in LA structure, LA mechanical function, and left ventricular remodeling occurred after 10 months of exercise but without significant change in atrial electrical activity. A longer duration of training may be required to induce electrical changes thought to cause atrial fibrillation in middle-aged endurance athletes. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique Identifier: NCT02039154.

Indexed as

Atrial Function, LeftAtrial RemodelingCardiomegaly, Exercise-InducedAtrial FibrillationCardiorespiratory FitnessEchocardiography, Doppler, PulsedElectrocardiographyFemaleHigh-Intensity Interval TrainingHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsTime FactorsVentricular Function, Leftathletesatrial fibrillationatrial remodelingechocardiographyexerciseyoga

Identifiers

PMID29748195
PMCPMC5951393
OpenAlexW2979827505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.