ArticleHeart, lung & circulation2019
Haemodynamically Derived Pulmonary Artery Pulsatility Index Predicts Mortality in Pulmonary Arterial Hypertension.
Article in Heart, lung & circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prognostic Value of Serial Risk Stratification in Adult and Pediatric Pulmonary Arterial Hypertension: A Systematic Review.Journal of the American Heart Association · 2024Pooled it
- Predictive Value of the Pulmonary Artery Pulsatility Index in Pulmonary Arterial Hypertension: REVEAL Analysis.Cardiology research · 2026Article
- Prognostic Value of the RVFWLS/PASP Ratio in Pulmonary Arterial Hypertension.Journal of cardiovascular development and disease · 2026Article
- The pulmonary artery pulsatility index in patients with severe aortic stenosis undergoing valve replacement.ESC heart failure · 2025Article
- Outcomes with venoarterial vs venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation in interstitial lung disease.JHLT open · 2025Article
- Echocardiography-Based Pulmonary Artery Pulsatility Index Correlates with Outcomes in Patients with Acute Pulmonary Embolism.Journal of clinical medicine · 2025Article
- Pulmonary Artery Pulsatility Index in Acute and Chronic Pulmonary Embolism.Medicina (Kaunas, Lithuania) · 2025Article
- Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation.Korean circulation journal · 2025Article
- Risk stratification and treatment goals in pulmonary arterial hypertension.The European respiratory journal · 2024Review
- The Pulmonary Artery Pulsatility Index Provides No Additional Prognostic Information in Pediatric Pulmonary Arterial Hypertension.Children (Basel, Switzerland) · 2024Article
- Management of the peri-intubation period in patients with pulmonary arterial hypertension and respiratory failure.Current cardiology reports · 2024Review
- Association between pulmonary artery pulsatility and mortality after implantation of left ventricular assist device.ESC heart failure · 2024Article
- Pulmonary Artery Pressures and Mortality During Venoarterial ECMO: An ELSO Registry Analysis.Circulation. Heart failure · 2024Article
- Prognostic role of haemodynamics at follow-up in patients with pulmonary arterial hypertension: a challenge to current European Society of Cardiology/European Respiratory Society risk tools.ERJ open research · 2024Article
- Persistence of pulmonary hypertension in patients undergoing ventricular assist devices and orthotopic heart transplantation.Pulmonary circulation · 2023Article
- Systemic arterial pulsatility (SAPi) in advanced heart failure: a novel hemodynamic risk stratification tool.Heart and vessels · 2023Article
- Association Between the Pulmonary Artery Pulsatility Index and Prognosis in Pulmonary Arterial Hypertension: A Multicentre Study.CJC open · 2023Article
- Real-time tracking of fibrinolysis under constant wall shear and various pulsatile flows in an in-vitro thrombolysis model.Bioengineering & translational medicine · 2023Article
- Parameter inference in a computational model of haemodynamics in pulmonary hypertension.Journal of the Royal Society, Interface · 2023Article
- Hemodynamic indices in pulmonary hypertension: a narrative review.Cardiovascular diagnosis and therapy · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPulmonary artery (PA) pulsitility index (PAPi) is a novel haemodynamic index shown to predict right ventricular failure in acute inferior myocardial infarction and post left ventricular assist device surgery. We hypothesised that PAPi calculated as [PA systolic pressure - PA diastolic pressure]/right atrial pressure (RAP) would be associated with mortality in the National Institutes of Health Registry for Primary Pulmonary Hypertension (NIH-RPPH).
methodsThe impact of PAPi, the Pulmonary Hypertension Connection (PHC) risk score, right ventricular stroke work, pulmonary artery capacitance (PAC), other haemodynamic indices, and demographic characteristics was evaluated in 272 NIH-RPPH patients using multivariable Cox proportional hazards (CPH) regression and receiver operating characteristic (ROC) analysis.
resultsIn the 272 patients (median age 37.7+/-15.9years, 63% female), the median PAPi was 5.8 (IQR 3.7-9.2). During 5years of follow-up, 51.8% of the patients died. Survival was markedly lower (32.8% during the first 3years) in PAPi quartile 1 compared with the remaining patients (58.5% over 3years in quartiles 2-4; p<0.0001). The best multivariable CPH survival model included PAPi, the PHC-Risk score, PAC, and body mass index (BMI). In this model, the adjusted hazard ratio for death with increasing PAPi was 0.946 (95% CI 0.905-0.989). The independent ROC areas for 5-year survival based on bivariable logistic regression for PAPi, BMI, PHC Risk, and PAC were 0.63, 0.62, 0.64, and 0.65, respectively (p<0.01). The ROC area for 5-year survival for the multivariable logistic model with all four covariates was 0.77 (p<0.0001).
conclusionsPulmonary artery pulsatility index was independently associated with survival in PAH, highlighting the utility of PAPi in combination with other key measures for risk stratification in this population.
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