Evidence map›Paper›PMID 29747856›Full record

ReviewTrends in neurosciences2018

Paradoxical Decision-Making: A Framework for Understanding Cognition in Parkinson's Disease.

Alessandra Perugini, Jochen Ditterich, Aasef G Shaikh, Barbara J Knowlton, Michele A Basso

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Preservation of Eye Movements in Parkinson's Disease Is Stimulus- and Task-Specific.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alessandra PeruginiFuster Laboratory of Cognitive Neuroscience, Department of Psychiatry and Biobehavioral Sciences, Department of Neurobiology, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, The David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Jochen DitterichCenter for Neuroscience and Department of Neurobiology, Physiology, and Behavior, University of California, Davis, CA, USA.
Aasef G ShaikhDepartment of Neurology, Case Western Reserve University, Cleveland, OH 44106, USA.
Barbara J KnowltonDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
Michele A BassoFuster Laboratory of Cognitive Neuroscience, Department of Psychiatry and Biobehavioral Sciences, Department of Neurobiology, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, The David Geffen School of Medicine, Los Angeles, CA 90095, USA. Electronic address: mbasso@mednet.ucla.edu.

Funding

Visual Target Selection for Saccadic Eye MovementsR01EY013692 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI BASSO, MICHELE A · 2002 to 2021
$7.0M
An in vitro model of saccadic eye movement choiceR01EY019663 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI BASSO, MICHELE A · 2010 to 2019
$3.5M
Visual Target Selection for Saccadic Eye MovementsR56EY013692 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI BASSO, MICHELE A · 2007 to 2007
$352k
NEI NIH HHS R01 EY013692NEI NIH HHS R01 EY019663NEI NIH HHS R56 EY013692
6 · The paper itself

Abstract

People with Parkinson's disease (PD) show impaired decision-making when sensory and memory information must be combined. This recently identified impairment results from an inability to accumulate the proper amount of information needed to make a decision and appears to be independent of dopamine tone and reinforcement learning mechanisms. Although considerable work focuses on PD and decisions involving risk and reward, in this Opinion article we propose that the emerging findings in perceptual decision-making highlight the multisystem nature of PD, and that unraveling the neuronal circuits underlying perceptual decision-making impairment may help in understanding other cognitive impairments in people with PD. We also discuss how a decision-making framework may be extended to gain insights into mechanisms of motor impairments in PD.

Indexed as

AnimalsCognitionDecision MakingHumansModels, NeurologicalParkinson Diseasebasal gangliadecision thresholddrift diffusion modelfreezing of gaitparadoxical movementperception

Identifiers

PMID29747856
PMCPMC6124671

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.