ArticleParasites & vectors2018
First report of Cytauxzoon sp. infection in domestic cats in Switzerland: natural and transfusion-transmitted infections.
Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- First Detection ofMicroorganisms · 2025Article
- Diversity ofPathogens (Basel, Switzerland) · 2025Article
- Sylvatic vector-borne pathogens including Cytauxzoon europaeus in the European wildcat (Felis silvestris) from southwestern Germany.Parasites & vectors · 2024Article
- Screening of Domestic Cats from North-Eastern Hungary forPathogens (Basel, Switzerland) · 2023Article
- Can Domestic Cats Act as Reservoirs ofPathogens (Basel, Switzerland) · 2023Article
- Apicomplexan haemoparasites in domestic cats in Romania.Parasites & vectors · 2023Article
- Cytauxzoon felis in salivary glands of Amblyomma americanum.Ticks and tick-borne diseases · 2023Article
- Molecular survey ofFrontiers in veterinary science · 2023Article
- Piroplasmid infection is not associated with clinicopathological and laboratory abnormalities in cats from Midwestern Brazil.Parasitology research · 2022Article
- The Piroplasmida Babesia, Cytauxzoon, and Theileria in farm and companion animals: species compilation, molecular phylogeny, and evolutionary insights.Parasitology research · 2022Review
- Babesiosis in Southeastern, Central and Northeastern Europe: An Emerging and Re-Emerging Tick-Borne Disease of Humans and Animals.Microorganisms · 2022Review
- The First Case ofAnimals : an open access journal from MDPI · 2022Article
- Article
- Cytauxzoon europaeus infections in domestic cats in Switzerland and in European wildcats in France: a tale that started more than two decades ago.Parasites & vectors · 2022Article
- Clinicopathological findings and risk factors associated withFrontiers in veterinary science · 2022Article
- Article
- 2021 ISFM Consensus Guidelines on the Collection and Administration of Blood and Blood Products in Cats.Journal of feline medicine and surgery · 2021Article
- Arthropod-Borne Pathogens in Stray Cats from Northern Italy: A Serological and Molecular Survey.Animals : an open access journal from MDPI · 2020Article
- Preliminary study of Cytauxzoon felis infection in outdoor cats in Mashhad, Iran.Parasitology research · 2020Article
- First report of Cytauxzoon sp. infection in Germany: organism description and molecular confirmation in a domestic cat.Parasitology research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytauxzoonosis is an emerging tick-borne disease of domestic and wild felids. Cytauxzoon felis induces severe and often fatal disease in domestic cats. In Europe, clinical and subclinical infections caused by Cytauxzoon sp. are described. We report the first cases of Cytauxzoon sp. infection in domestic cats in Switzerland.
methodsClinical and laboratory data and results of PCR analyses were collected from Cytauxzoon sp. PCR-positive cats and the cats followed for up to 851 days.
resultsThe cases were three two-month old kittens from the same litter (Cases 1-3) and two adult domestic shorthair cats (Cases 4 and 5). The cats originated from the north-west and west of Switzerland. Cases 1-3 presented with moderate to severe regenerative anaemia and intraerythrocytic inclusions. Cytauxzoon sp. was confirmed by PCR and sequencing. The kittens made a clinical and haematological recovery after blood transfusion and/or treatment with azithromycin and atovaquone, but erythroparasitaemia persisted. Case 4 presented with severe non-regenerative anaemia. Case 5 was healthy and used as a blood donor for Case 4. Following blood transfusion, Case 4 showed intraerythrocytic inclusions, and Cytauxzoon sp. was confirmed in both Cases 4 and 5 using PCR and sequencing. Case 4 achieved clinical and haematological remission after treatment with azithromycin, atovaquone and immunosuppressive drugs. Eight months later, Case 4 was presented again with anaemia but tested Cytauxzoon sp. PCR-negative. Sequencing of 1637 bp of the 18S rRNA gene of Cytauxzoon sp. revealed 100% nucleotide sequence identity among isolates of Cases 1-3 and between isolates of Cases 4 and 5, and 99% sequence identity between isolates of all cases. Phylogenetic analysis revealed the closest relationship of the Swiss isolates to Cytauxzoon sp. isolates from domestic cats and wild felids from France, Spain and Romania and to Cytauxzoon manul from a Pallas's cat.
conclusionsThis is the first report of Cytauxzoon sp. infection in domestic cats in Switzerland. It is also the first report of infection in very young kittens and transmission of Cytauxzoon sp. to an adult cat by transfusion of blood from an asymptomatic cat. The cats recovered but some developed chronic asymptomatic erythroparasitaemia for up to 28 months. Domestic cats may act as reservoirs for Cytauxzoon sp. in Europe and blood donor cats should be screened for this agent by PCR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.