Evidence map›Paper›PMID 29747621›Full record

ArticleBMC ophthalmology2018

Prevalence and clinical characteristics of dry eye disease in community-based type 2 diabetic patients: the Beixinjing eye study.

Xinrong Zou, Lina Lu, Yi Xu, Jianfeng Zhu, Jiangnan He, Bo Zhang, Haidong Zou

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06573606 (Ophthalmic Solution in Diabetic Corneal Alteration), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06573606 completednot on this mapstarted 2021, after this paper: background citation

Ophthalmic Solution in Diabetic Corneal Alteration

Typeobservational_patient_registrySponsorD&V FARMA srlRan2021 to 2022Enrolled20ConditionsDry Eye Disease (DED)ArmsCX-HA and CS
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

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  19. Tear film layers and meibomian gland assessment in patients with type 1 diabetes mellitus using a noninvasive ocular surface analyzer: a cross-sectional case-control study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  20. Tear proteomics in dry eye disease.Indian journal of ophthalmology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xinrong ZouShanghai General Hospital, Nanjing Medical University, No. 100, Haining Road, Hongkou District, Shanghai, 200080, China.
Lina LuDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, No. 380, Kangding Road, Jingan, Shanghai, 200040, China.
Yi XuDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, No. 380, Kangding Road, Jingan, Shanghai, 200040, China.
Jianfeng ZhuDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, No. 380, Kangding Road, Jingan, Shanghai, 200040, China.
Jiangnan HeDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, No. 380, Kangding Road, Jingan, Shanghai, 200040, China.
Bo ZhangDepartment of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, No. 380, Kangding Road, Jingan, Shanghai, 200040, China.
Haidong ZouShanghai General Hospital, Nanjing Medical University, No. 100, Haining Road, Hongkou District, Shanghai, 200080, China. zouhaidong@hotmail.com.
Shanghai Eye Disease Prevention & Treatment Center · CNNanjing Medical University · CN

Funding

Chinese National Nature Science Foundation 81670898Shanghai High-level Oversea Training Team Program on Eye Public Health GWTD2015S08Shanghai Outstanding Academic Leader Program 16XD1402300Shanghai Pujiang Program PJ(2012) 0001652Shanghai Three Year Public Health Action Program GWIV-3.3the Chronic Diseases Prevention and Treatment Project of Shanghai Shen Kang Hospital Development Centre SHDC12015315
6 · The paper itself

Abstract

backgroundThis study was performed to evaluate the prevalence and clinical characteristics of dry eye disease (DED) in community-based type 2 diabetic patients and to identify the associated factors related with DED.

methodsA total of 1360 type 2 diabetic patients in the Beixinjing community were randomly selected. All participants were given a questionnaire that assessed basic information and subjective symptoms.DED was diagnosed using the revised Japanese DED diagnostic criteria. All subjects underwent a routine ophthalmic examination, corneal sensitivity test, tear film break-up time(BUT) test, Schirmer I test, fluorescein and lissamine green staining(FL) and fundus photography. Diabetic retinopathy (DR) was graded according to the International severity scale of diabetic retinopathy and diabetic macular edema.

resultsOf the 1360 subjects, 238 (17.5%) were diagnosed with DED. There was a significant association between the presence of DED and higher blood glucose (P < 0.001, OR1.240) as well as higher levels of glycosylated hemoglobin HbA1c (P < 0.001, OR1.108). Corneal sensitivity was negatively correlated with the prevalence of DED (P = 0.02, OR0.973).

conclusionsThe prevalence of DED in this community-based study was 17.5%, which was lower than that observed in hospital-based studies. Diabetic patients with poor metabolic control were more likely to present with DED. A dry eye examination should be added to the routine screening of diabetes.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesChinaCorneaCross-Sectional StudiesDiabetes Mellitus, Type 2Diabetic RetinopathyDry Eye SyndromesFemaleFluoresceinHumansMaleMiddle AgedPrevalenceFluoresceinCommunity-basedDry eye diseasePrevalenceType 2 diabetic patients

Identifiers

PMID29747621
PMCPMC5946388
OpenAlexW2807430675

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.