Evidence map›Paper›PMID 29747418›Full record

ArticleNutrients2018

Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells.

Peng Liu, Wei Wang, Zhigang Zhou, Andrew J O Smith, Richard P Bowater, Ian Michael Wormstone, Yuqiong Chen, Yongping Bao

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Peng LiuNorwich Medical School, University of East Anglia, Norfolk, Norwich NR4 7UQ, UK. P.Liu5@uea.ac.uk.
Wei WangNorwich Medical School, University of East Anglia, Norfolk, Norwich NR4 7UQ, UK. wei.wang@uea.ac.uk.
Zhigang ZhouNorwich Medical School, University of East Anglia, Norfolk, Norwich NR4 7UQ, UK. zhigang.zhou@ipswichhospital.nhs.uk.
Andrew J O SmithSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK. a.j.smith3@uea.ac.uk.
Richard P BowaterSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK. r.bowater@uea.ac.uk.ORCID 0000-0002-2745-7807
Ian Michael WormstoneSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk NR4 7TJ, UK. I.M.Wormstone@uea.ac.uk.
Yuqiong ChenCollege of Horticulture and Forestry Science Huazhong Agricultural University, Wuhan 430070, China. chenyq@mail.hzau.edu.cn.
Yongping BaoNorwich Medical School, University of East Anglia, Norfolk, Norwich NR4 7UQ, UK. Y.Bao@uea.ac.uk.ORCID 0000-0002-6425-0370
University of East Anglia · GBHuazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulforaphane (SFN) exhibits chemopreventive effects through various mechanisms. However, few studies have focused on the bioactivities of its metabolites. Here, three metabolites derived from SFN were studied, known as sulforaphane glutathione, sulforaphane cysteine and sulforaphane-

Indexed as

AcetylcysteineAnticarcinogenic AgentsAntioxidant Response ElementsCell AdhesionCell MovementCell SurvivalComet AssayDNA DamageDose-Response Relationship, DrugGlutathioneHep G2 CellsHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideIsothiocyanatesNF-E2-Related Factor 2AcetylcysteineAnticarcinogenic AgentsGlutathioneHydrogen PeroxideIsothiocyanatesNFE2L2 protein, humanNF-E2-Related Factor 2sulforaphaneSulfoxideschemopreventionGSHNrf2sulforaphanesulforaphane metabolites

Identifiers

PMID29747418
PMCPMC5986465
OpenAlexW2802895290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.