ReviewDiagnostics (Basel, Switzerland)2018
The Clinical Relevance of Methods for Handling Inconclusive Medical Test Results: Quantification of Uncertainty in Medical Decision-Making and Screening.
Review in Diagnostics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Performance of a consensus-based algorithm for diagnosing anastomotic leak after minimally invasive esophagectomy for esophageal cancer.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Trial
- An analysis of the real world performance of an artificial intelligence based autism diagnostic.Scientific reports · 2025Article
- Article
- Missing values and inconclusive results in diagnostic studies - A scoping review of methods.Statistical methods in medical research · 2023Article
- Article
- Machine learning with asymmetric abstention for biomedical decision-making.BMC medical informatics and decision making · 2021Article
- On the information hidden in a classifier distribution.Scientific reports · 2021Article
- Forensic science and the principle of excluded middle: "Inconclusive" decisions and the structure of error rate studies.Forensic science international. Synergy · 2021Article
- Optimal threshold of the prostate health index in predicting aggressive prostate cancer using predefined cost-benefit ratios and prevalence.International urology and nephrology · 2020Article
- Diagnostic potential of simplified methods for measuring glomerular filtration rate to detect chronic kidney disease in dogs.Journal of veterinary internal medicine · 2019Article
- Impact of the Prevalence of Cognitive Impairment on the Accuracy of the Montreal Cognitive Assessment: The Advantage of Using two MoCA Thresholds to Identify Error-prone Test Scores.Alzheimer disease and associated disordersArticle
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1 author.
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Abstract
backgroundalthough the existence of inconclusive medical test results or bio-markers is widely recognized, there are indications that this inherent diagnostic uncertainty is sometimes ignored. This paper discusses three methods for defining and determining inconclusive medical test results, which use different definitions and differ in clinical relevance.
methodsthe TG-ROC (two graphs receiver operating characteristics) method is the easiest to use, while the grey zone method and the uncertain interval method require more extensive calculations.
resultsthis paper discusses the technical details of the methods, as well as advantages and disadvantages for their clinical use. TG-ROC and the grey zone method can help in the acquisition of high rates of diagnostic certainty, but can exclude large groups. The uncertain interval method can prevent decisions that are the most uncertain, invalid and unreliable, while excluding smaller groups.
conclusionsthe identification of uncertain test scores is relevant, because these scores indicate the need to obtain better information or to await further developments. The methods presented help to determine inconclusive test scores and can help to reduce erroneous decisions. However, further research and development is desirable.
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