ArticleTranslational oncology2018
Molecular Characterization of Colorectal Signet-Ring Cell Carcinoma Using Whole-Exome and RNA Sequencing.
Article in Translational oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma.British journal of cancer · 2019Trial
- Distinct genomic landscape of colorectal signet ring cell carcinoma reveals frequent KMT2 family alterations and SMAD4 inactivation.BMC cancer · 2026Article
- Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma.Journal of the National Cancer Center · 2026Article
- Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma.NPJ precision oncology · 2025Article
- Molecular characteristics of patients with colorectal signet-ring cell carcinoma with different ABO blood groups.Heliyon · 2024Article
- Inherited KDM6AOncogene · 2024Article
- Gastrointestinal signet ring cell malignancy: current advancement and future prospects.Investigational new drugs · 2023Review
- Case Report: Systemic treatment for breast and vulvar metastases from resected rectal signet ring cell carcinoma.Frontiers in oncology · 2023Article
- A novel DNA methylation signature associated with lymph node metastasis status in early gastric cancer.Clinical epigenetics · 2022Article
- A Rare Case of Signet Ring Cell Colon Cancer Presenting as Adult Colorectal Intussusception.Case reports in pathology · 2022Article
- Nomograms to predict individual prognosis of patients with primary signet ring cell carcinoma of the urinary bladder.Translational cancer research · 2021Article
- Incidence of and Risk Factors for Gastroepiploic Lymph Node Involvement in Patients with Cancer of the Transverse Colon Including the Hepatic Flexure.World journal of surgery · 2021Article
- Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.Pathology oncology research : POR · 2021Review
- Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in rectal cancer.International journal of clinical oncology · 2020Article
- Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.Protein & cell · 2020Article
- Signet Ring Cell Carcinoma of the Colon in Young Adults: A Case Report and Literature Review.Case reports in oncological medicine · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSignet-ring cell carcinoma (SRCC) is a very rare subtype of colorectal adenocarcinoma (COAD) with a poor clinical prognosis. Although understanding key mechanisms of tumor progression in SRCCs is critical for precise treatment, a comprehensive view of genomic alterations is lacking. MATERIALS AND
methodsWe performed whole-exome sequencing of tumors and matched normal blood as well as RNA sequencing of tumors and matched normal colonic tissues from five patients with SRCC.
resultsWe identified major somatic alterations and characterized transcriptional changes at the gene and pathway level. Based on high-throughput sequencing, the pattern of mutations and copy number variations was overall similar to that of COAD. Transcriptome analysis revealed that major transcription factors, such as SRF, HNF4A, ZEB1, and RUNX1, with potential regulatory roles in key pathways, including focal adhesion, the PI3K-Akt signaling pathway, and the MAPK signaling pathway, may play a role in the tumorigenesis of SRCC. Furthermore, significantly upregulated genes in SRCCs were enriched for epithelial-mesenchymal transition genes, and accumulation of mucin in intracytoplasm was associated with the overexpression of MUC2.
conclusionThe results indicate that the molecular basis of colorectal SRCC exhibits key differences from that of consensus COAD. Our findings clarify important genetic features of particular abnormalities in SRCCs.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.