ArticleRedox biology2018
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Abstract read
In one paragraph
Article in Redox biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed.
- Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026Review
- Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Review
- Immunosenescence in Idiopathic Pulmonary Fibrosis.Journal of inflammation research · 2026Review
- Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk.Journal of translational medicine · 2025Article
- Low-Dose radiation risk in medicine: a look at risk models, challenges, and future prospects.Zeitschrift fur medizinische Physik · 2025Review
- The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging.Ageing research reviews · 2025Review
- Attenuation of Cellular Senescence and Improvement of Osteogenic Differentiation Capacity of Human Liver Stem Cells Using Specific Senomorphic and Senolytic Agents.Stem cell reviews and reports · 2025Article
- Review
- Redox regulation: mechanisms, biology and therapeutic targets in diseases.Signal transduction and targeted therapy · 2025Review
- Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.Aging cell · 2025Article
- The Ercc1Aging cell · 2025Article
- Multidimensional mechanisms of quercetin in diabetic kidney disease.Frontiers in cell and developmental biology · 2025Review
- Beyond polarization: macrophage senescence in immunoregulation and cancer therapy.International journal of biological sciences · 2025Review
- Transcriptional stress in aging: integrating experimental data and modeling to quantify DNA damage accumulation.Frontiers in molecular biosciences · 2025Article
- Beyond Nucleotide Excision Repair: The Importance of XPF in Base Excision Repair and Its Impact on Cancer, Inflammation, and Aging.International journal of molecular sciences · 2024Review
- Review
- The brain-body energy conservation model of aging.Nature aging · 2024Review
- Senescence- and Immunity-Related Changes in the Central Nervous System: A Comprehensive Review.Aging and disease · 2024Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors.
Andria R RobinsonDepartment of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA; University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Matthew J YousefzadehDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Tania A RozgajaDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Jin WangDepartment of Chemistry, University of California, Riverside, CA 92521, USA.
Xuesen LiDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Jeremy S TilstraDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
Chelsea H FeldmanUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Siobhán Q GreggUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Caroline H JohnsonThe Scripps Research Institute California, La Jolla, CA 92037, USA.
Erin M SkodaDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Marie-Céline FrantzDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Harris Bell-TeminDepartment of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Hannah Pope-VarsalonaDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Aditi U GurkarDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Luigi A NastoDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Paediatric Orthopaedics, G. Gaslini Children's Hospital, Genoa, Italy.
Renã A S RobinsonDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Heike Fuhrmann-StroissniggDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Jolanta CzerwinskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Sara J McGowanDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Nadiezhda Cantu-MedellinVascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jamie B HarrisDepartment of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA.
Salony ManiarCenter for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Mark A RossCenter for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Christy E TrussoniDivision of Gastroenterology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA.
Nicholas F LaRussoDivision of Gastroenterology and Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA.
Eugenia Cifuentes-PaganoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Patrick J PaganoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Barbara TudekInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Nam V VoDepartment of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Lora H RigattiUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA.
Patricia L OpreskoUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Donna B StolzDepartment of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Simon C WatkinsDepartment of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Christin E BurdDepartment of Molecular Genetics, Cancer Biology and Genetics, The Ohio State University, Columbus OH 43210 USA.
Claudette M St CroixDepartment of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Gary SiuzdakThe Scripps Research Institute California, La Jolla, CA 92037, USA.
Nathan A YatesDepartment of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Biomedical Mass Spectrometry Center, Schools of the Health Sciences University of Pittsburgh, Pittsburgh, PA 15213, USA.
Paul D RobbinsUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, CA 92521, USA.
Peter WipfDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Eric E KelleyDepartment of Physiology & Pharmacology, West Virginia University, Morgantown, WV 26506, USA. Electronic address: eric.kelley@hsc.wvu.edu.
Laura J NiedernhoferUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA 15232, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address: lniedern@scripps.edu.
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0MTraining and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4MVARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5MWest Virginia University Stroke COBREP20GM109098 · NIGMS · WEST VIRGINIA UNIVERSITY · PI HRUSKA, MARTIN · 2014 to 2024
$24.5MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon · 2015 to 2026
$14.1MPROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2MOxidative DNA Damage and CpG MutagenesisR01CA101864 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2004 to 2015
$2.8MThe contribution of DNA interstrand crosslinks to agingR01ES016114 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIEDERNHOFER, LAURA JANE · 2007 to 2011
$2.5MProgressive degenerative role of Nox and thrombospondin-1 in the aging vasculatureR01HL142248 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 2019 to 2022
$2.3MThe role of cellular senescence in intervertebral disc agingR01AG044376 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VO, NAM V · 2013 to 2017
$1.5MLiver Regeneration as a Model for AngiogenesisR01CA076541 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOLZ, DONNA BEER · 2004 to 2008
$1.1MNCI NIH HHS P30 CA047904NCI NIH HHS R01 CA076541NCI NIH HHS R01 CA101864NCI NIH HHS R29 CA076541NHLBI NIH HHS R01 HL142248NIAID NIH HHS U19 AI068021NIA NIH HHS K99 AG049126NIA NIH HHS P01 AG043376NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG044271NIA NIH HHS R00 AG036817NIA NIH HHS R00 AG049126NIA NIH HHS R01 AG044376NIA NIH HHS U19 AG056278NIEHS NIH HHS R01 ES016114NIGMS NIH HHS P20 GM109098
Abstract
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1
Indexed as
AgingAnimalsAntioxidantsCellular SenescenceCyclic N-OxidesDNA-Binding ProteinsDNA DamageDNA RepairEndonucleasesHumansMiceMice, KnockoutMitochondriaOxidation-ReductionOxidative StressReactive Oxygen SpeciesAntioxidantsCyclic N-OxidesDNA-Binding ProteinsEndonucleasesErcc1 protein, mouseReactive Oxygen SpeciesXJB-5-131AgingCellular senescenceEndogenous DNA damageFree radicalsGenotoxic stressOxidative lesionsReactive oxygen species
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.