ArticleMolecular biology and evolution2018
Adaptation of S. cerevisiae to Fermented Food Environments Reveals Remarkable Genome Plasticity and the Footprints of Domestication.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed.
- Transcriptomic shift in ethanol and amino acid metabolic genes regulated by Med15 during alcoholic fermentation.Microbial genomics · 2026Article
- Genomic signatures of dairy adaptation inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic background shapes the transcriptional activity and phenotypic contribution of a horizontally acquired region in yeast.Molecular biology and evolution · 2026Article
- Horizontal gene transfer in Saccharomyces cerevisiae and other Saccharomycotina yeasts: a review.World journal of microbiology & biotechnology · 2026Review
- From Oak to Wine: Evolution, Admixture, and Adaptation of California and British Columbia Saccharomyces Cerevisiae Wine Strains.Genome biology and evolution · 2026Article
- Genotypic and Phenotypic Diversity of Maudiozyma humilis: The Multiple Evolutionary Trajectories of a Domesticated Yeast.Genome biology and evolution · 2026Article
- Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phylogenomic diversity of clinicalMicrobiology spectrum · 2026Article
- Microbial ecology of fermented foods.FEMS yeast research · 2026Review
- Genomic tales of wine yeasts: from domestication to functional innovation.FEMS yeast research · 2026Review
- Uncorking wine yeast genomics from grape to glass.FEMS yeast research · 2026Review
- From one genome to thousands, and beyond.FEMS yeast research · 2026Review
- Article
- Footprints of Human Migration in the Population Structure of Wild Baker's Yeast.Molecular ecology · 2025Article
- Harboring Starships: The Accumulation of Large Horizontal Gene Transfers in Domesticated and Pathogenic Fungi.Genome biology and evolution · 2025Article
- Phylogenomics and functional annotation of 530 non-Studies in mycology · 2025Article
- Optogenetic control of horizontally acquired genes prevent stuck fermentations in yeast.Microbiology spectrum · 2025Article
- Horizontal Transfer and Recombination Fuel Ty4 Retrotransposon Evolution in Saccharomyces.Genome biology and evolution · 2025Article
- Comparative adaptability of 307Frontiers in microbiology · 2025Article
- Understanding brewing trait inheritance inmSystems · 2024Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The budding yeast Saccharomyces cerevisiae can be found in the wild and is also frequently associated with human activities. Despite recent insights into the phylogeny of this species, much is still unknown about how evolutionary processes related to anthropogenic niches have shaped the genomes and phenotypes of S. cerevisiae. To address this question, we performed population-level sequencing of 82 S. cerevisiae strains from wine, flor, rum, dairy products, bakeries, and the natural environment (oak trees). These genomic data enabled us to delineate specific genetic groups corresponding to the different ecological niches and revealed high genome content variation across the groups. Most of these strains, compared with the reference genome, possessed additional genetic elements acquired by introgression or horizontal transfer, several of which were population-specific. In addition, several genomic regions in each population showed evidence of nonneutral evolution, as shown by high differentiation, or of selective sweeps including genes with key functions in these environments (e.g., amino acid transport for wine yeast). Linking genetics to lifestyle differences and metabolite traits has enabled us to elucidate the genetic basis of several niche-specific population traits, such as growth on galactose for cheese strains. These data indicate that yeast has been subjected to various divergent selective pressures depending on its niche, requiring the development of customized genomes for better survival in these environments. These striking genome dynamics associated with local adaptation and domestication reveal the remarkable plasticity of the S. cerevisiae genome, revealing this species to be an amazing complex of specialized populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.