ArticleNucleic acids research2018
INTERSPIA: a web application for exploring the dynamics of protein-protein interactions among multiple species.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Exposure of Toluene Diisocyanate Induces DUSP6 and p53 through Activation of TRPA1 Receptor.International journal of molecular sciences · 2022Article
- Revealing the Angiopathy of Lacrimal Gland Lesion in Type 2 Diabetes.Frontiers in physiology · 2021Article
- Evolutionary and Functional Analysis of Korean Native Pig Using Single Nucleotide Polymorphisms.Molecules and cells · 2020Article
- Leveraging User-Friendly Network Approaches to Extract Knowledge From High-ThroughputFrontiers in genetics · 2019Review
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Authors and funding
6 authors.
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Abstract
Proteins perform biological functions through cascading interactions with each other by forming protein complexes. As a result, interactions among proteins, called protein-protein interactions (PPIs) are not completely free from selection constraint during evolution. Therefore, the identification and analysis of PPI changes during evolution can give us new insight into the evolution of functions. Although many algorithms, databases and websites have been developed to help the study of PPIs, most of them are limited to visualize the structure and features of PPIs in a chosen single species with limited functions in the visualization perspective. This leads to difficulties in the identification of different patterns of PPIs in different species and their functional consequences. To resolve these issues, we developed a web application, called INTER-Species Protein Interaction Analysis (INTERSPIA). Given a set of proteins of user's interest, INTERSPIA first discovers additional proteins that are functionally associated with the input proteins and searches for different patterns of PPIs in multiple species through a server-side pipeline, and second visualizes the dynamics of PPIs in multiple species using an easy-to-use web interface. INTERSPIA is freely available at http://bioinfo.konkuk.ac.kr/INTERSPIA/.
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