ArticlePloS one2018
Opportunistic osteoporosis screening via the measurement of frontal skull Hounsfield units derived from brain computed tomography images.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- Automated opportunistic screening for low bone mineral density using routine CT brain imaging.Frontiers in radiology · 2026Article
- Osteoporosis screening and major osteoporotic fracture prediction by cranial computed tomography-derived Hounsfield units: a multi-center study on opportunistic osteoporosis screening.Annals of medicine · 2025Article
- Opportunistic screening for osteoporosis using routine clinical care computed tomography brain studies.Skeletal radiology · 2025Article
- Skull Density Ratio as Arm-Allocation Parameter for a Controlled Focused Ultrasound Trial in Parkinson's Disease.Movement disorders clinical practice · 2024Article
- Stroke recurrence and osteoporotic conditions in postmenopausal patients with atherosclerotic ischemic stroke.Heliyon · 2024Article
- Risk Factor Analysis of Cryopreserved Autologous Bone Flap Resorption in Adult Patients Undergoing Cranioplasty with Volumetry Measurement Using Conventional Statistics and Machine-Learning Technique.Journal of Korean Neurosurgical Society · 2024Article
- Routine chest CT combined with the osteoporosis self-assessment tool for Asians (OSTA): a screening tool for patients with osteoporosis.Skeletal radiology · 2023Article
- Opportunistic measures of bone mineral density at multiple skeletal sites during whole-body CT in polytrauma patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Low skull bone density is associated with poor motor prognosis in women with Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Correlation between Hounsfield unit derived from head, thorax, abdomen, spine and pelvis CT and t-scores from DXA.Skeletal radiology · 2021Article
- Article
- Effects of Possible Osteoporotic Conditions on the Recurrence of Chronic Subdural Hematoma.Frontiers in neurology · 2020Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeOsteoporosis is one of the most common chronic metabolic diseases, but detection and treatment rates are low. The aim of the current study was to evaluate the correlation between frontal skull Hounsfield unit (HU) values from brain computed tomography (CT) scans and T-scores of the lumbar spine and femoral neck from dual-energy X-ray absorptiometry (DXA) scans.
methodsPatients with < 1 year between brain CT and DXA scans were included in the study. The average frontal skull HU value used for analysis was defined as the average of four HU values of the frontal bone. A receiver operating characteristic curve was generated, and area under the curve (AUC) was used to determine the HU values of the frontal skull for predicting osteoporosis. The frontal skull HU value with the highest sensitivity and specificity was considered the optimal cutoff value.
resultsIn total, 899 patients who underwent both brain CT and DXA scans at a single institution were enrolled. Average skull HU values differed significantly among patients in different bone mineral density categories (p < 0.001). There was a positive correlation between skull HU value and T-score (β = 105.06, p < 0.001, R2 = 0.343). The mean HU value in subjects with osteoporosis was 515, and the optimal cutoff value for the prediction of osteoporosis was 610 HU (AUC = 0.775, 95% CI 0.744-0.806, p < 0.001).
conclusionsClinical brain CT scans can assist in the detection of osteoporosis, and patients with an HU value < 610 as determined via brain CT may be considered for further evaluation for possible osteoporosis.
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