ReviewPLoS neglected tropical diseases2018
New insights into leishmaniasis in the immunosuppressed.
Review in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 119 citations in OpenAlex.
- Assessment of Systemic Inflammation as a Tool for Estimating the Risk of Death by Visceral Leishmaniasis.Pathogens (Basel, Switzerland) · 2026Article
- Revisiting visceral leishmaniasis in immunocompromised patients: Ongoing gaps and advances in diagnostics, therapies, and preventive measures.Current research in parasitology & vector-borne diseases · 2026Review
- Direct sequencing of Leishmania donovani from patients in Garissa County, Northern Kenya, reveals a newly emerging intra-specific hybrid genotype.PLoS neglected tropical diseases · 2026Article
- Leishmaniasis.Nature reviews. Disease primers · 2025Review
- Screening for Leishmania spp. infection in patients treated with biologic agents for immune-mediated inflammatory diseases: results of an Italian multicentric prospective study.Tropical medicine and health · 2025Article
- Article
- A case of relapsing visceral leishmaniasis: the potential role of steroids and RANKL inhibitors in worsening disease outcome.ASM case reports · 2025Article
- Immune-Pathological Correlates of Disease Severity in New-World Kala-Azar: The Role of Parasite Load and Cytokine Profiles.Pathogens (Basel, Switzerland) · 2025Article
- Co-endemicity of schistosomiasis and tegumentary leishmaniasis: Spatial co-clustering in endemic areas.Tropical medicine & international health : TM & IH · 2025Article
- Impact of Marasmic Malnutrition on Visceral Leishmaniasis: Progression and Treatment Efficacy in a Murine Model.Nutrients · 2025Article
- Evaluation of Beauvericin's activity and mode of action against all life stages ofFrontiers in cellular and infection microbiology · 2025Article
- Screening for anti-Leishmania antibodies and Leishmania infections in kidney transplant recipients and donors from Brazil.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Association between clinical outcomes, peripheral blood and cytomorphologic features of bone marrow in visceral leishmaniasis.Hematology, transfusion and cell therapy · 2024Article
- Feline leishmaniosis in the Mediterranean Basin: a multicenter study.Parasites & vectors · 2024Article
- Chronic High-Level Parasitemia in HIV-Infected Individuals With or Without Visceral Leishmaniasis in an Endemic Area in Northwest Ethiopia: Potential Superspreaders?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Serological Screening and Risk Factors Associated withMicroorganisms · 2024Article
- Epidemiological and clinical trends of visceral leishmaniasis in Portugal: retrospective analysis of cases diagnosed in public hospitals between 2010 and 2020.Infectious diseases of poverty · 2024Article
- Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148.Organic process research & development · 2024Article
- The spleen is the graveyard of CD4+ cells in patients with immunological failure of visceral leishmaniasis and AIDS.Parasites & vectors · 2024Article
- Upregulation of PD-1/PD-L1 and downregulation of immune signaling pathways lead to more severe visceral leishmaniasis in undernutrition mice.Parasites & vectors · 2024Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL). HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the most important immunosuppression-related factors. This review briefly describes the challenges of these associations. East Africa and the Indian subcontinent are the places where HIV imposes the highest burden in VL. In the highlands of Northern Ethiopia, migrant rural workers are at a greater risk of coinfection and malnutrition, while in India, HIV reduces the sustainability of a successful elimination programme. As shown from a longitudinal cohort in Madrid, VL is an additional threat to solid organ transplantation. The association with malnutrition is more complex since it can be both a cause and a consequence of VL. Different regimes for therapy and secondary prevention are discussed as well as the role of nutrients on the prophylaxis of VL in poverty-stricken endemic areas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.