Evidence map›Paper›PMID 29746376›Full record

Trial reportThe Pediatric infectious disease journal2018

Neruodevelopmental Outcomes in Preschool Children Living With HIV-1 Subtypes A and D in Uganda.

Horacio Ruiseñor-Escudero, Alla Sikorskii, Itziar Familiar-Lopez, Deborah Persaud, Carrie Ziemniak, Noeline Nakasujja, Robert Opoka, Michael Boivin

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Pediatric infectious disease journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Neurocognitive Complications of Pediatric HIV Infections.Current topics in behavioral neurosciences · 2021
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Horacio Ruiseñor-EscuderoFrom the Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lancing, MI.
Alla SikorskiiFrom the Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lancing, MI.
Itziar Familiar-LopezFrom the Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lancing, MI.
Deborah PersaudDepartments of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD.
Carrie ZiemniakDepartments of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD.
Noeline NakasujjaMakerere University, Department of Psychiatry, Kampala, Uganda.
Robert OpokaMakerere University, Department of Pediatrics, Kampala, Uganda.
Michael BoivinFrom the Department of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lancing, MI.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Enhancing Ugandan HIV-Affected Child Development with Caregiver TrainingR01HD070723 · NICHD · MICHIGAN STATE UNIVERSITY · PI BASS, JUDITH KAREN, BOIVIN, MICHAEL JOSEPH · 2011 to 2015
$2.8M
NIAID NIH HHS P30 AI094189NICHD NIH HHS R01 HD070723
6 · The paper itself

Abstract

backgroundHIV is a neuropathogenic virus that may result in detrimental neurodevelopmental (ND) outcomes early in life. This is the first study to evaluate the effect of HIV-1 subtype on neurodevelopment of Ugandan preschool children.

methodsNeurodevelopment of 87 HIV-1 infected and 221 HIV exposed uninfected Ugandan children 1.8-4.9 years of age was assessed using 4 scales of the Mullen Scales of Early Learning (MSEL), 2 scales of the Color Object Association Test (COAT), and 1 score of the Early Childhood Vigilance Test. HIV-1 subtype was defined by phylogenetic analyses. General linear models were used to relate test scores to HIV-1 subtype (A versus D) while adjusting for relevant covariates. The scores were benchmarked against HIV exposed uninfected group to facilitate the interpretation.

resultsSeventy-one percentage of children infected with subtype A versus 60% of children with subtype D were currently on antiretroviral therapy (P = 0.49). Children with HIV-1 subtype A infection were older when compared with subtype D (3.29 vs. 2.76 years, respectively, P = 0.03), but similar regarding sex, socioeconomic status, weight-for-age z-score, CD4+ and CD8+ (% and total), viral load. No statistically significant differences by HIV-1 subtype were observed in the MSEL, COAT and Early Childhood Vigilance Test. Differences ≥ 0.33 of the SD were observed for the MSEL Composite Score, Receptive Language (MSEL) and Total Memory (COAT).

conclusionsIn contrast to previously reported differences in ND outcomes of school-age children by HIV-1 subtype, ND scores among preschool children were similar for subtypes A and D, with few potential differences on language production and memory outcomes that favored subtype A. Further investigation with larger sample sizes and longitudinal follow-up is needed.

Indexed as

Child DevelopmentChild, PreschoolCross-Sectional StudiesFemaleHIV-1HIV InfectionsHumansInfantMaleNeurodevelopmental DisordersNeurologic ExaminationUganda

Identifiers

PMID29746376
PMCPMC6226335

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.