Evidence map›Paper›PMID 29746241›Full record

ArticleMethods in enzymology2018

Fe-S Clusters and MutY Base Excision Repair Glycosylases: Purification, Kinetics, and DNA Affinity Measurements.

Nicole N Nuñez, Chandrima Majumdar, Kori T Lay, Sheila S David

Open access · greenAbstract read
In one paragraph

Article in Methods in enzymology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Damage sensor role of UV-DDB during base excision repair.Nature structural & molecular biology · 2019
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nicole N NuñezUniversity of California, Davis, CA, United States.
Chandrima MajumdarUniversity of California, Davis, CA, United States.
Kori T LayUniversity of California, Davis, CA, United States.
Sheila S DavidUniversity of California, Davis, CA, United States. Electronic address: ssdavid@ucdavis.edu.
University of California, Davis · USUniversity of California System · US

Funding

RECOGNITION AND REPAIR OF MISMATCHED DNA BY MUTYR01CA067985 · NCI · UNIVERSITY OF UTAH · PI DAVID, SHEILA SUE · 2000 to 2025
$5.6M
UC Davis Training Program in Chemical BiologyT32GM113770 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEAL, PETER A. · 2015 to 2019
$742k
NCI NIH HHS R01 CA067985NIGMS NIH HHS T32 GM113770
6 · The paper itself

Abstract

A growing number of iron-sulfur (Fe-S) cluster cofactors have been identified in DNA repair proteins. MutY and its homologs are base excision repair (BER) glycosylases that prevent mutations associated with the common oxidation product of guanine (G), 8-oxo-7,8-dihydroguanine (OG) by catalyzing adenine (A) base excision from inappropriately formed OG:A mispairs. The finding of an [4Fe-4S]

Indexed as

AnimalsCloning, MolecularDNADNA DamageDNA GlycosylasesDNA RepairEnzyme AssaysEscherichia coliGene ExpressionGeobacillus stearothermophilusHumansIron-Sulfur ProteinsKineticsMiceModels, MolecularDNADNA GlycosylasesIron-Sulfur ProteinsmutY adenine glycosylaseDNA damageDNA–protein interactionsDNA repairEnzyme kineticsFe–S clusterProtein purification

Identifiers

PMID29746241
PMCPMC6267926
OpenAlexW2783219164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.