Evidence map›Paper›PMID 29746206›Full record

ReviewTissue barriers2018

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.

Sergio E Chiarella, Erik E Rabin, Lorena A Ostilla, Annette S Flozak, Cara J Gottardi

Open access · hybridAbstract readReview
In one paragraph

Review in Tissue barriers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sergio E Chiarellaa Department of Medicine.
Erik E Rabina Department of Medicine.ORCID 0000-0002-8967-6482
Lorena A Ostillaa Department of Medicine.
Annette S Flozaka Department of Medicine.
Cara J Gottardia Department of Medicine.ORCID 0000-0003-0912-7617
Northwestern University · US

Funding

Northwestern University Allergy Immunology Research Program (NUAIR)T32AI083216 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2010 to 2026
$4.1M
NIAID NIH HHS T32 AI083216
6 · The paper itself

Abstract

α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

Indexed as

alpha CateninAnimalsHeart DiseasesHumansHypersensitivityNervous System Diseasesalpha CateninCTNNA3 protein, humanadherens junctionsasthmaBiology of epithelial barrierscadherinscardiomyopathycatenins, actincell-cell adhesionDesmosomesneurologicalsignaling

Identifiers

PMID29746206
PMCPMC6179130
OpenAlexW2801415927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.