ArticleJournal of the American Chemical Society2018
Constructing Smart Protocells with Built-In DNA Computational Core to Eliminate Exogenous Challenge.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- DNA-empowered synthetic cells as minimalistic life forms.Nature reviews. Chemistry · 2024Review
- Lipid vesicle-based molecular robots.Lab on a chip · 2024Review
- Programming DNA Reaction Networks Using Allosteric DNA Hairpins.Biomolecules · 2023Article
- Light-Activated Membrane Transport in Polymeric Cell-Mimics.Angewandte Chemie (International ed. in English) · 2022Article
- Network topology-directed design of molecular CPU for cell-like dynamic information processing.Science advances · 2022Article
- Advances in Applications of Molecular Logic Gates.ACS omega · 2021Review
- Bioinspired Networks of Communicating Synthetic Protocells.Frontiers in molecular biosciences · 2021Review
- Lipid-oligonucleotide conjugates for bioapplications.National science review · 2020Article
- Nanoparticle-based computing architecture for nanoparticle neural networks.Science advances · 2020Article
- Protocells programmed through artificial reaction networks.Chemical science · 2019Review
- DNA Nanotechnology Enters Cell Membranes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
A DNA reaction network is like a biological algorithm that can respond to "molecular input signals", such as biological molecules, while the artificial cell is like a microrobot whose function is powered by the encapsulated DNA reaction network. In this work, we describe the feasibility of using a DNA reaction network as the computational core of a protocell, which will perform an artificial immune response in a concise way to eliminate a mimicked pathogenic challenge. Such a DNA reaction network (RN)-powered protocell can realize the connection of logical computation and biological recognition due to the natural programmability and biological properties of DNA. Thus, the biological input molecules can be easily involved in the molecular computation and the computation process can be spatially isolated and protected by artificial bilayer membrane. We believe the strategy proposed in the current paper, i.e., using DNA RN to power artificial cells, will lay the groundwork for understanding the basic design principles of DNA algorithm-based nanodevices which will, in turn, inspire the construction of artificial cells, or protocells, that will find a place in future biomedical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.