ArticleJournal of the American Chemical Society2018
Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Palladium-catalyzed enantioselective alkenylation of acyclic alkenols: Broad scope with alkenyl bromides.Science advances · 2026Article
- Divergent Access to α,β-Unsaturated Thiolated and Selenolated Lactams via a Unified Palladium-Catalyzed Carbonylative Transformation.Organic letters · 2026Article
- Ligand-controlled divergent enantioselective hydroarylation of cyclobutenes.Chemical science · 2025Article
- Facile construction of distal and diversified tertiary and quaternary stereocenters.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synthesis of 2,6-Organic letters · 2024Article
- Immobilization of Trifluoromethyl-Substituted Pyridine-Oxazoline Ligand and Its Application in Asymmetric Continuous Flow Synthesis of Benzosultams.The Journal of organic chemistry · 2023Article
- Arylboration of Enecarbamates for the Synthesis of Borylated Saturated N-Heterocycles.Angewandte Chemie (International ed. in English) · 2022Article
- γ-Selective C(spNature communications · 2021Article
- Rate Profiling the Impact of Remote Functional Groups on the Redox-Relay Heck Reaction.Organic letters · 2021Article
- 2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Stereoselective Remote Functionalization via Palladium-Catalyzed Redox-Relay Heck Methodologies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy.Advanced synthesis & catalysis · 2020Article
- Article
- Nickel-catalyzed intermolecular oxidative Heck arylation driven by transfer hydrogenation.Nature communications · 2019Article
- Three-component vicinal-diarylation of alkenesChemical science · 2019Article
- Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives.Chemical science · 2019Article
- Palladium-Catalyzed Enantioselective Alkenylation of Enelactams Using a Relay Heck Strategy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Asymmetric δ-Lactam Synthesis with a Monomeric Streptavidin Artificial Metalloenzyme.Journal of the American Chemical Society · 2019Article
- Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates.Angewandte Chemie (International ed. in English) · 2019Article
- 11-Step Total Synthesis of Teleocidins B-1-B-4.Journal of the American Chemical Society · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
In this Communication, we describe the construction of chiral α,β-unsaturated δ-lactams, widely used as pharmacophores, in high yields and excellent enantioselectivities using an oxidative relay Heck arylation reaction. This strategy also allows facile access to 7-substituted α,β-unsaturated ε-lactam products and δ-lactams containing a tetrasubstituted nitrogen-bearing stereocenter.
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