Evidence map›Paper›PMID 29745997›Full record

ArticleStem cells translational medicine2018

Efficacy of Human Placental-Derived Stem Cells in Collagen VII Knockout (Recessive Dystrophic Epidermolysis Bullosa) Animal Model.

Yanling Liao, Larisa Ivanova, Rajarajeswari Sivalenka, Trevor Plumer, Hongwen Zhu, Xiaokui Zhang, Angela M Christiano, John A McGrath, Jodi P Gurney, Mitchell S Cairo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Progress in skin gene therapy: From the inside and out.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  7. Review
  8. Stem Cells Translational Medicine.Stem cells translational medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Yanling LiaoDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Larisa IvanovaDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Rajarajeswari SivalenkaCelgene Cellular Therapeutics, Warren, New Jersey, USA.
Trevor PlumerDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.
Hongwen ZhuDepartment of Surgery, Tianjin Hospital, Tianjin Academy of Integrative Medicine, Tianjin, People's Republic of China.
Xiaokui ZhangCelgene Cellular Therapeutics, Warren, New Jersey, USA.
Angela M ChristianoDepartment of Dermatology, Columbia University Medical Center, New York, New York, USA.
John A McGrathSt John's Institute of Dermatology, King's College, London, United Kingdom.
Jodi P GurneyCelgene Cellular Therapeutics, Warren, New Jersey, USA.
Mitchell S CairoDepartment of Pediatrics, New York Medical College, Valhalla, New York, USA.ORCID 0000-0002-2075-434X
New York Medical College · USBristol-Myers Squibb (Switzerland) · CHColumbia University Irving Medical Center · USKing's College London · GBTianjin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating inherited skin blistering disease caused by mutations in the COL7A1 gene that encodes type VII collagen (C7), a major structural component of anchoring fibrils at the dermal-epidermal junction (DEJ). We recently demonstrated that human cord blood-derived unrestricted somatic stem cells promote wound healing and ameliorate the blistering phenotype in a RDEB (col7a1

Indexed as

Stem Cell TransplantationAnimalsAntibodiesCollagen Type VIIDisease Models, AnimalEpidermolysis Bullosa DystrophicaFemaleHumansIntestine, SmallKaplan-Meier EstimateMiceMice, Inbred C57BLMice, KnockoutPlacentaPregnancySkinAntibodiesCol7a1 protein, mouseCollagen Type VIICellular therapyClinical translationPlacentaStem cell transplantationStem/progenitor cellTransgenic mouse

Identifiers

PMID29745997
PMCPMC6052609
OpenAlexW2802013889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.