Evidence map›Paper›PMID 29745896›Full record

ArticleeLife2018

Neolithic and medieval virus genomes reveal complex evolution of hepatitis B.

Ben Krause-Kyora, Julian Susat, Felix M Key, Denise Kühnert, Esther Bosse, Alexander Immel, Christoph Rinne, Sabin-Christin Kornell, Diego Yepes, Sören Franzenburg and 12 more

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Recovery of an 18bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Ben Krause-Kyora *Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0001-9435-2872
Julian Susat *Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Felix M KeyMax Planck Institute for the Science of Human History, Jena, Germany.ORCID http://orcid.org/0000-0003-2812-6636
Denise KühnertMax Planck Institute for the Science of Human History, Jena, Germany.
Esther BosseInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Alexander ImmelInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Christoph RinneInstitute of Pre- and Protohistoric Archaeology, Kiel University, Kiel, Germany.
Sabin-Christin KornellInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Diego YepesSystematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Kiel University, Kiel, Germany.
Sören FranzenburgInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Henrike O HeyneStanley Center for Psychiatric Research, Broad Institute, Cambridge, United States.
Thomas MeierInstitute for Pre- and Protohistory and Near Eastern Archaeology, Heidelberg University, Heidelberg, Germany.
Sandra LöschDepartment of Physical Anthropology, Institute of Forensic Medicine, University of Bern, Bern, Switzerland.
Harald MellerState Office for Heritage Management and Archaeology Saxony-Anhalt, State Museum of Prehistory, Halle, Germany.
Susanne FriederichState Office for Heritage Management and Archaeology Saxony-Anhalt, State Museum of Prehistory, Halle, Germany.
Nicole NicklischState Office for Heritage Management and Archaeology Saxony-Anhalt, State Museum of Prehistory, Halle, Germany.
Kurt W AltState Office for Heritage Management and Archaeology Saxony-Anhalt, State Museum of Prehistory, Halle, Germany.
Stefan SchreiberInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Andreas TholeySystematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Kiel University, Kiel, Germany.
Alexander HerbigMax Planck Institute for the Science of Human History, Jena, Germany.
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Johannes KrauseMax Planck Institute for the Science of Human History, Jena, Germany.ORCID http://orcid.org/0000-0001-9144-3920

Funding

European Research Council APGREIDSwiss National Science Foundation PMPDP3_171320/1
6 · The paper itself

Abstract

The hepatitis B virus (HBV) is one of the most widespread human pathogens known today, yet its origin and evolutionary history are still unclear and controversial. Here, we report the analysis of three ancient HBV genomes recovered from human skeletons found at three different archaeological sites in Germany. We reconstructed two Neolithic and one medieval HBV genome by

Indexed as

Evolution, MolecularGenome, ViralFossilsGermanyHepatitis B virusHumansPhylogenyProteomeSequence Analysis, DNASkeletonViral ProteinsProteomeViral Proteinsancient DNAancient pathogensgeneticsgenomicshepatitis Bhuman evolutioninfectious diseasemicrobiologynext generation sequencingvirus evolution

Identifiers

PMID29745896
PMCPMC6008052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.