ArticleConnective tissue research2018
Novel insights into renal mineralization and stone formation through advanced imaging modalities.
Article in Connective tissue research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Co-occurrence of nephrocalcinosis and nephrolithiasis in feline kidneys.Journal of veterinary internal medicine · 2026Article
- The silent epidemic of CKDu: advances, challenges, and strategies for sustainable eradication-a narrative review.Clinical and experimental nephrology · 2025Review
- Functional analysis reveals calcium-sensing receptor gene regulating cell-cell junction in renal tubular epithelial cells.International urology and nephrology · 2024Article
- Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen.Journal of cellular and molecular medicine · 2024Review
- Identification of TIMPs signatures in Randall plaque from single-cell RNA sequencing (scRNA-Seq) analysis.Functional & integrative genomics · 2024Article
- Mitochondria-derived vesicles and their potential roles in kidney stone disease.Journal of translational medicine · 2023Review
- Multidisciplinary investigation of an ancient renal stone in a mummy from Popoli, central Italy.Pathologica · 2022Article
- Osteopontin: An important protein in the formation of kidney stones.Frontiers in pharmacology · 2022Review
- Recent advances on the mechanisms of kidney stone formation (Review).International journal of molecular medicine · 2021Review
- Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation.Nature reviews. Nephrology · 2021Review
- Osteogenic Differentiation of Renal Interstitial Fibroblasts Promoted by lncRNAFrontiers in cell and developmental biology · 2020Article
- [Current concepts on the pathogenesis of urinary stones].Der Urologe. Ausg. A · 2019Review
- Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Purpose/Aim: The most common kidney stone composed of calcium oxalate forms on interstitial calcium phosphate mineral known as a Randall's plaque (RP). Due to limited information about events leading to the initial deposition of nanometer size interstitial calcium phosphate pre-clusters, there continues to be a debate on the initial site of calcium phosphate deposition and factors leading to stone formation. MATERIALS AND
methodsHigh-resolution X-ray micro-computed tomography (CT), and light and electron microscopy techniques were used to characterize human renal pyramids and five representative kidney stones with identifiable stems. Mineral densities of mineralized aggregates within these specimens were correlated with micro- and ultra-structures as seen using light and electron microscopy techniques.
resultsThe earliest detectable biominerals in the human renal papilla were proximal intratubular plate-like calcium phosphate deposits. Unoccluded tubules in stems connected to calcium phosphate stones were observed by electron microscope and X-ray micro-CT. These tubules were similar in diameter (30-100 μm) and shape to those observed in the distal regions of the renal papilla.
conclusionsObservations were patterned through a novel and unified theory of stepwise-architecture guided biomineralization (a combination of smaller structures leading to a larger but similar structural framework). A plausible stepwise progression in renal biomineralization is proposed; proximal intratubular calcium phosphate deposits can lead to interstitial yet calcium phosphate rich RP and mature into a stem on which a calcium oxalate stone grows within the collecting system of a kidney.
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